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Fibrate Therapy Cuts Risk and Slows Progression of Diabetic Retinopathy, Study Finds

Taiwan: Fibrate therapy may offer a promising strategy for preventing and managing diabetic retinopathy (DR), a leading cause of vision loss among people with diabetes. A new comprehensive systematic review and meta-analysis has concluded that fibrates not only reduce the onset of DR but also slow its long-term progression, without adding any major safety risks.
- Fibrate therapy lowered the incidence of diabetic retinopathy (DR) by 28% compared to placebo.
- It reduced the long-term progression of DR by 33%.
- The addition of fibrates to standard statin therapy further reduced DR progression by 17% compared to fibrates alone.
- Although the reduction in risk of progression to proliferative DR was not statistically significant, the trend still favored fibrate use.
- No increase in serious adverse events or overall mortality was observed, highlighting a neutral safety profile.
- The pooled data confirmed no significant difference between fibrates and placebo in terms of all-cause mortality or severe adverse events, providing reassurance about safety.
Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751