- Home
- Medical news & Guidelines
- Anesthesiology
- Cardiology and CTVS
- Critical Care
- Dentistry
- Dermatology
- Diabetes and Endocrinology
- ENT
- Gastroenterology
- Medicine
- Nephrology
- Neurology
- Obstretics-Gynaecology
- Oncology
- Ophthalmology
- Orthopaedics
- Pediatrics-Neonatology
- Psychiatry
- Pulmonology
- Radiology
- Surgery
- Urology
- Laboratory Medicine
- Diet
- Nursing
- Paramedical
- Physiotherapy
- Health news
- Fact Check
- Bone Health Fact Check
- Brain Health Fact Check
- Cancer Related Fact Check
- Child Care Fact Check
- Dental and oral health fact check
- Diabetes and metabolic health fact check
- Diet and Nutrition Fact Check
- Eye and ENT Care Fact Check
- Fitness fact check
- Gut health fact check
- Heart health fact check
- Kidney health fact check
- Medical education fact check
- Men's health fact check
- Respiratory fact check
- Skin and hair care fact check
- Vaccine and Immunization fact check
- Women's health fact check
- AYUSH
- State News
- Andaman and Nicobar Islands
- Andhra Pradesh
- Arunachal Pradesh
- Assam
- Bihar
- Chandigarh
- Chattisgarh
- Dadra and Nagar Haveli
- Daman and Diu
- Delhi
- Goa
- Gujarat
- Haryana
- Himachal Pradesh
- Jammu & Kashmir
- Jharkhand
- Karnataka
- Kerala
- Ladakh
- Lakshadweep
- Madhya Pradesh
- Maharashtra
- Manipur
- Meghalaya
- Mizoram
- Nagaland
- Odisha
- Puducherry
- Punjab
- Rajasthan
- Sikkim
- Tamil Nadu
- Telangana
- Tripura
- Uttar Pradesh
- Uttrakhand
- West Bengal
- Medical Education
- Industry
Optic nerve head hemoglobin measurements help in early diagnosis of primary open angle glaucoma: Study
In a new study published in Glaucoma, it was seen that using measurements of optic nerve head (ONH) hemoglobin concentrations, the Laguna ONhE program may offer a reliable and affordable method of identifying early primary open angle glaucoma (POAG).
The Laguna ONhE, a program that analyses fundus photos to determine the hemoglobin (Hb) content of the optic nerve head, showed high accuracy in differentiating between healthy and eyes with moderate glaucoma. In order to differentiate between healthy eyes and eyes with moderate glaucoma, Livia Studart de Meneses and colleagues conducted this investigation with the goal of measuring the Hb content of the optic nerve.
For this study, both healthy volunteers (n=64) and patients with mild primary open angle glaucoma (MD > 6 dB) had their eyes chosen. All eyes' retinal nerve fiber layer thicknesses were measured using optical coherence tomography. Additionally, optic disc pictures were acquired, and the images were examined using the Laguna ONhE program, which calculates the quantity of Hb in 24 ONH sectors. The Glaucoma Discriminant Function (GDF), an index that quantifies the likelihood that the ONH is consistent with glaucoma, is also computed by the program. Each Laguna ONhE parameter's areas under the receiver operating characteristic curve and sensitivities at preset specificities of 90% and 95% were computed.
The key findings of this study were as follows:
1. The mean nerve fiber of retinal layer thickness and vertical cup/disc ratio of the two given groups, control and glaucoma were 90.0±10.6 m and 66.28±9.85 m, respectively, and 0.5±0.09 vs 0.65±0.09.
2. Total Hb was considerably greater in the control group (67.9±4.45 vs. 62.89±4.89, P0.001), as was GDF (11.57±15.34 vs. 27.67±20.94, P0.001).
3. The Hb concentration in the control group was likewise substantially greater in 21 of the 24 sectors compared to the glaucoma group (P0.05).
4. The GDF exhibited the greatest area under the receiver operating characteristic curve (0.93), with 79.3% sensitivity and 95% fixed specificity.
In conclusion, analyses of optic nerve Hb content using a colorimetry photographic instrument indicated strong discrimination between healthy and moderate glaucoma eyes. More research is needed to understand the vascular variables involved in the development of glaucoma.
Reference:
Meneses, L. S. de, Ciarlini, L. R., Ayub, G., Vasconcellos, J. P. C., & Costa, V. P. (2022). Discrimination Between Healthy Eyes and Those With Mild Glaucoma Damage Using Hemoglobin Measurements of the Optic Nerve Head. In Journal of Glaucoma (Vol. 31, Issue 7, pp. 567–573). Ovid Technologies (Wolters Kluwer Health). https://doi.org/10.1097/ijg.0000000000002026
Neuroscience Masters graduate
Jacinthlyn Sylvia, a Neuroscience Master's graduate from Chennai has worked extensively in deciphering the neurobiology of cognition and motor control in aging. She also has spread-out exposure to Neurosurgery from her Bachelor’s. She is currently involved in active Neuro-Oncology research. She is an upcoming neuroscientist with a fiery passion for writing. Her news cover at Medical Dialogues feature recent discoveries and updates from the healthcare and biomedical research fields. She can be reached at editorial@medicaldialogues.in
Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751