Abnormal immune suppression linked to poor healing of bone injury: Study

Written By : Medha Baranwal |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2021-02-24T06:45:34+05:30 | Updated On 24 Feb 2021 12:56 PM IST

USA: Increased circulating levels of MDSCs and IL-10 (immunosuppressor cells) is associated with poor functional regeneration of traumatic bone injuries, suggests a recent study in the Proceedings of the National Academy of Sciences.

The results suggest that the early systemic immune response to trauma can be helpful in predicting the long-term effectiveness of bone healing and may inform immunotherapies development for orthopedic repair.

Severe traumatic injuries results in chronic nonunion that presents a widespread and challenging clinical problem and delayed treatment of an established nonunion is associated with variable outcomes and often prolonged patient disability. Despite this, the factors that drive successful healing and restoration of function are still not well understood. Dysregulated immune response following injury is known to be one recently identified risk factor for poor healing outcomes.

The researchers used a rodent model of nonunion with delayed treatment to investigate the factors that influence effective healing.

In a preclinical model of orthopedic trauma, Albert Cheng, Georgia Institute of Technology, Atlanta, GA, and colleagues demonstrate that distinct systemic immune profiles are correlated with impaired bone regeneration.

"Most notably, elevated blood levels of myeloid-derived suppressor cells (MDSCs) and the immunosuppressive cytokine interleukin-10 (IL-10) are negatively correlated with functional bone regeneration as early as 1 wk posttreatment," they wrote.

"We found that certain immune profiles are linked to impaired bone regeneration. In particular, increased early levels of myeloid-derived suppressor cells and the cytokine interleukin-10 in blood are predictive of subsequent poor healing outcomes," concluded the authors.

"These results suggest that the early systemic immune response to trauma can help predict the long-term effectiveness of bone healing treatments and may inform the development of immunotherapies for orthopedic repair."

The study titled, "Early systemic immune biomarkers predict bone regeneration after trauma," is published in the Proceedings of the National Academy of Sciences.

DOI: https://www.pnas.org/content/118/8/e2017889118

Proceedings of the National Academy of Sciencesbone nonuniontraumatic bone injuryhealingimmune response

Source : Proceedings of the National Academy of Sciences

Medha Baranwal

MSc. Biotechnology

Medha Baranwal joined Medical Dialogues as an Editor in 2018 for Speciality Medical Dialogues. She covers several medical specialties including Cardiac Sciences, Dentistry, Diabetes and Endo, Diagnostics, ENT, Gastroenterology, Neurosciences, and Radiology. She has completed her Bachelors in Biomedical Sciences from DU and then pursued Masters in Biotechnology from Amity University. She has a working experience of 5 years in the field of medical research writing, scientific writing, content writing, and content management. She can be contacted at editorial@medicaldialogues.in. Contact no. 011-43720751

Dr. Kamal Kant Kohli

Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751