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  • Enoxaparin as...

Enoxaparin as effective as aspirin for lowering symptomatic VTE risk after arthroplasty: JAMA

Written By : Jacinthlyn Sylvia |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2023-06-12T09:00:54+05:30  |  Updated On 9 Oct 2023 3:36 PM IST
Enoxaparin as effective as aspirin for lowering symptomatic VTE risk after arthroplasty: JAMA
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A secondary analysis of a cluster randomized crossover clinical trial done by The CRISTAL Study Group discovered that there was no difference in mortality after 90 days between patients assigned to enoxaparin versus aspirin for venous thromboembolism (VTE) prevention. The findings of this study were published in The Journal of American Medical Association.

Following hip and knee arthroplasty, ischemic heart disease remains the major cause of death. Aspirin has been postulated as a medication that might lower mortality when administered as venous thromboembolism prophylaxis following these operations due to its antiplatelet and cardioprotective effects. As a result, this study compared aspirin to enoxaparin in terms of lowering 90-day mortality in patients after hip or knee arthroplasty surgeries.

This was a planned secondary analysis of the CRISTAL cluster randomized, crossover, registry-nested trial, which was conducted in 31 Australian hospitals between April 20, 2019, and December 18, 2020. The CRISTAL study sought to establish if aspirin was superior to enoxaparin in preventing symptomatic VTE after hip or knee arthroplasty. The primary research limited the analysis to individuals who had complete hip or knee arthroplasty for osteoarthritis. All adult patients (aged 18 years) receiving any hip or knee arthroplasty operation at participating facilities during the trial are included in this study. Data was analyzed between June 1 and September 6, 2021. The primary endpoint was death within 90 days. The mortality difference between groups was calculated using cluster summary techniques.

The key findings of this study were:

1. A total of 23 458 patients from 31 institutions were involved, with 14 156 assigned to aspirin and 9302 assigned to enoxaparin.

2. Within 90 days of surgery, the aspirin group had a death rate of 1.67% while the enoxaparin group had a mortality rate of 1.53%.

3. The death rate in the subgroup of 21 148 patients with a non fracture diagnosis was 0.49% in the aspirin group and 0.41% in the enoxaparin group.

Reference:

Sidhu, V. S., Kelly, T.-L., Pratt, N., Graves, S. E., Buchbinder, R., Adie, S., Cashman, K., Ackerman, I. N., Bastiras, D., Brighton, R., Burns, A. W. R., Chong, B. H., Ellis, A., … Harris, I. A. (2023). Effect of Aspirin vs Enoxaparin on 90-Day Mortality in Patients Undergoing Hip or Knee Arthroplasty. In JAMA Network Open (Vol. 6, Issue 6, p. e2317838). American Medical Association (AMA). https://doi.org/10.1001/jamanetworkopen.2023.17838

Enoxaparinaspirinvenous thromboembolismJAMA Network Open
Source : JAMA Network Open
Jacinthlyn Sylvia
Jacinthlyn Sylvia

    Neuroscience Masters graduate

    Jacinthlyn Sylvia, a Neuroscience Master's graduate from Chennai has worked extensively in deciphering the neurobiology of cognition and motor control in aging. She also has spread-out exposure to Neurosurgery from her Bachelor’s. She is currently involved in active Neuro-Oncology research. She is an upcoming neuroscientist with a fiery passion for writing. Her news cover at Medical Dialogues feature recent discoveries and updates from the healthcare and biomedical research fields. She can be reached at editorial@medicaldialogues.in

    Dr. Kamal Kant Kohli
    Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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