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  • Platelet-rich plasma...

Platelet-rich plasma improves healing of acute patellar tendon defect if injected early after injury: Study

Dr. Shravani DaliWritten by Dr. Shravani Dali Published On 2024-11-15T20:00:04+05:30  |  Updated On 15 Nov 2024 8:00 PM IST
Platelet-rich plasma improves  healing of acute patellar tendon defect if injected early after injury: Study
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Platelet-rich plasma improves healing of acute patellar tendon defect if injected early after injury suggests a study published in the BMC Musculoskeletal Disorders.

There is no consensus on the frequency and timing of platelet-rich plasma (PRP) injection in tendon healing. We aimed to evaluate the effectiveness of single versus multiple PRP injections in the healing of patellar tendon defects in the experimental model, through histological and biomechanical investigation. Forty-four male skeletally mature Dutch rabbits were randomly divided into the five study groups ( A, B,C, D,E). After creating a longitudinal acute patellar tendon defect on both knees (One-third the width of the patella tendon), the right legs of the rabbits were used as the intervention group and the left legs as the control groups. Animals in groups A, B, and C were euthanized on days 7, 14, and 28, respectively, after the first PRP injection. Animals in group D received the second PRP injection on day 10 and was euthanized on day 14. Animals in group D received the second and third PRP injections on days 10 and 20, respectively, and were euthanized on day 28. The outcomes were evaluated histologically (modification of Movin’s Grading) and biomechanically. Results

The inflammatory condition was exaggerated in groups D and E. Load at failure was higher in the non-injected side of groups D and E, while there was no significant difference between the right and left legs of the three groups A, B and C. In other word, groups with a single PRP injection were more resistant to the increasing load compared to the groups with multiple PRP injections. PRP improves tendon healing if injected early after injury, while its injection after the initial phase of injury hampers tendon healing. In addition, a single PRP injection seems to be more effective than multiple PRP injection. Therefore, in cases where PRP injection is indicated for tendon repair, such as acute tendon injury, we recommend using a single PRP injection during tendon repair surgery.

Reference:

Ghaderi, M.T., Momenzadeh, O.R., Jaberi, F.M. et al. Effect of a single versus serial platelet-rich plasma injection on acute patellar tendon defect healing: an experimental study. BMC Musculoskelet Disord 25, 684 (2024). https://doi.org/10.1186/s12891-024-07804-4

Keywords:

Platelet-rich, plasma, improves, healing, acute, patellar, tendon, defect, injected, early, after, injury, study, Ghaderi, M.T., Momenzadeh, O.R., Jaberi, F.M, Platelet-rich plasma, Tendon defect, Patellar tendon, Rabbit model, Knee, BMC Musculoskeletal Disorders


Platelet-richplasmaimproveshealingacutepatellartendondefectinjectedearlyafterinjurystudy
Source : BMC Musculoskeletal Disorders
Dr. Shravani Dali
Dr. Shravani Dali

    Dr. Shravani Dali has completed her BDS from Pravara institute of medical sciences, loni. Following which she extensively worked in the healthcare sector for 2+ years. She has been actively involved in writing blogs in field of health and wellness. Currently she is pursuing her Masters of public health-health administration from Tata institute of social sciences. She can be contacted at editorial@medicaldialogues.in.

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