Preoperative LCR can predict mortality and complications in displaced displaced femoral neck facture

Written By : Dr. Shravani Dali |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2022-11-28T20:00:14+05:30 | Updated On 29 Nov 2022 3:51 PM IST

The low level of preoperative Lymphocyte-to-C-reactive protein (CRP) ratio (LCR) can effectively predict 1-year mortality and 30-day total complications after surgery in elderly patients with displaced femoral neck facture undergoing hemiarthroplasty suggests a recent study published in the Journal of Orthopaedic Surgery and Research

Lymphocyte-to-C-reactive protein (CRP) ratio (LCR) is a novel biomarker for predicting poor prognosis in many diseases. This study aims to analyze the association between preoperative LCR and 1-year mortality in elderly patients with displaced femoral neck facture undergoing hemiarthroplasty.

Between May 2017 and May 2019, a retrospective study including 364 elderly patients undergoing hemiarthroplasty for displaced FNF was performed. LCR was defined as the ratio of preoperative lymphocyte count to CRP level. The optimal cutoff value of LCR was determined by receiver operating characteristic curve, and all patients were categorized into low-LCR group and high-LCR group accordingly. The relationship between LCR and 1-year mortality was evaluated by using univariate and multivariate Cox regression analysis. Furthermore, the complications within 30 days after surgery, length of hospital stay, and perioperative red blood cell transfusion were also analyzed stratified by LCR.

Results:

A total of 47 patients (12.9%) died within 1-year follow-up after surgery.
The optimal cutoff value for LCR was 30,560
Low-LCR (≤ 30,560) group had a higher mortality rate than high-LCR group
In multivariate analysis, low LCR, hypoalbuminemia, and Age-Adjusted Charlson Comorbidity Index ≥ 6 were identified as independent predictors for 1-year mortality. Moreover, low level of LCR was associated with high rate of total complications perioperative transfusions, and longer hospital stay

The low level of preoperative LCR can effectively predict 1-year mortality and 30-day total complications after surgery in elderly patients with displaced FNF undergoing hemiarthroplasty.

Reference:

Zhu, J., Cheng, X., Li, Y. et al. Low lymphocyte-to-C-reactive protein ratio relates to high 1-year mortality in elderly patients undergoing hemiarthroplasty for displaced femoral neck facture. J Orthop Surg Res 17, 512 (2022). https://doi.org/10.1186/s13018-022-03406-9

Keywords:

Zhu, J., Cheng, X., Li, Y, Low, lymphocyte-to-C-reactive, protein, ratio, relates, high 1-year, mortality, elderly patients, undergoing, hemiarthroplasty, displaced, femoral neck facture, Journal of Orthopaedic Surgery and Research, Elderly, Femoral neck fracture, Hemiarthroplasty, Mortality, Lymphocyte-to-C-reactive protein ratio

ElderlyFemoral neck fractureHemiarthroplastyMortalityLymphocyte-to-C-reactive protein ratioJournal of Orthopaedic Surgery and Research

Source : Journal of Orthopaedic Surgery and Research

Dr. Shravani Dali

Dr. Shravani Dali has completed her BDS from Pravara institute of medical sciences, loni. Following which she extensively worked in the healthcare sector for 2+ years. She has been actively involved in writing blogs in field of health and wellness. Currently she is pursuing her Masters of public health-health administration from Tata institute of social sciences. She can be contacted at editorial@medicaldialogues.in.

Dr. Kamal Kant Kohli

Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751