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Rheumatoid Arthritis Patients Face Higher Risk of Kidney Stones: Study

Written By : Dr. Shravani Dali |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2025-09-14T21:00:21+05:30  |  Updated On 15 Sept 2025 12:18 PM IST
Rheumatoid Arthritis Patients Face Higher Risk of Kidney Stones: Study
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Kidney stone disease remains a growing health concern worldwide, with metabolic, inflammatory, and lifestyle factors all contributing to risk. New research now suggests that individuals with rheumatoid arthritis (RA) may be particularly vulnerable.

In a large population-based study involving nearly 20,000 participants, researchers found that patients with RA experienced more than double the incidence of kidney stones compared to those without the condition.

The association persisted even after adjusting for common risk factors such as age, sex, and comorbidities, highlighting a potential link between systemic inflammation and stone formation. Rheumatoid arthritis is a chronic autoimmune disease characterized by persistent joint inflammation and systemic immune dysregulation.

Researchers propose several possible mechanisms that could explain the elevated risk of nephrolithiasis in RA patients. Chronic inflammation may alter calcium and uric acid metabolism, leading to increased urinary excretion and crystal deposition.

Additionally, medications frequently used in RA management-such as corticosteroids and diuretics-may contribute to stone formation by influencing fluid balance and renal handling of minerals. Reduced physical activity and dietary modifications in RA patients could also indirectly affect risk. Importantly, the study’s design limited causal inference. While the findings underscore a significant association, they do not establish that RA directly causes kidney stones.

Instead, the results suggest that RA may act as a clinical marker of increased susceptibility, requiring further mechanistic and longitudinal research to clarify causality. Clinically, these findings carry important implications. Physicians caring for RA patients should be aware of the heightened risk of nephrolithiasis and consider proactive monitoring, especially in individuals with additional metabolic risk factors. Lifestyle strategies such as hydration, balanced diets, and metabolic screening may help mitigate risks. Overall, the study highlights the broader systemic burden of RA beyond joint disease, adding kidney stones to the list of potential comorbidities requiring integrated care.

Reference:

Yue, G., Yan, Y., Zeng, X. et al. Association between rheumatoid arthritis and kidney stones: A cross-sectional study of NHANES 2007–2020. Arthritis Res Ther 27, 141 (2025). https://doi.org/10.1186/s13075-025-03604-w

rheumatoid arthritiskidney stonesnephrolithiasisautoimmune diseaseinflammationmetabolic riskcomorbidityuric acidcorticosteroidscohort study
Source : Arthritis Research & Therapy |
Dr. Shravani Dali
Dr. Shravani Dali

    Dr. Shravani Dali has completed her BDS from Pravara institute of medical sciences, loni. Following which she extensively worked in the healthcare sector for 2+ years. She has been actively involved in writing blogs in field of health and wellness. Currently she is pursuing her Masters of public health-health administration from Tata institute of social sciences. She can be contacted at editorial@medicaldialogues.in.

    Dr. Kamal Kant Kohli
    Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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