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  • Sinusitis, 'common...

Sinusitis, 'common cold' tied with increased risk of rheumatoid arthritis: study

Written By : Dr. Shravani Dali |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2021-12-28T09:00:05+05:30  |  Updated On 28 Dec 2021 9:00 AM IST
Sinusitis, common cold tied with increased risk of rheumatoid arthritis: study
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Sinusitis, the 'common cold' tied with an increase risk for developing rheumatoid arthritis, according to a new study published in the Journal of Rheumatology.

A group of researchers aimed to determine whether specific respiratory tract diseases are associated with increased rheumatoid arthritis (RA) risk.

This case-control study within the Mass General Brigham Biobank matched newly diagnosed RA cases to three controls on age, sex, and electronic health record history. They identified RA using a validated algorithm and confirmed by medical record review. Respiratory tract disease exposure required one inpatient or two outpatient codes at least two years before the index date of RA clinical diagnosis or matched date. Logistic regression models calculated odds ratios (OR) for RA with 95% confidence intervals (CI), adjusting for confounders. The researchers then stratified by serostatus ("seropositive" was a positive rheumatoid factor and/or anti-citrullinated protein antibodies) and smoking.

The Results of the study are as follows:

The researchers identified 741 RA cases and 2,223 controls (both median age 55, 76% female). Acute sinusitis (OR 1.61, 95% CI:1.05,2.45), chronic sinusitis (OR 2.16, 95% CI:1.39,3.35), and asthma (OR 1.39, 95% CI:1.03,1.87) were associated with increased risk of RA. Acute respiratory tract disease burden during the pre-index exposure period was also associated with increased RA risk (OR 1.30 per 10 codes, 95% CI:1.08,1.55). Acute pharyngitis was associated with seronegative (OR 1.68, 95% CI:1.02,2.74) but not seropositive RA; chronic rhinitis/pharyngitis was associated with seropositive (OR 2.46, 95% CI:1.01,5.99) but not seronegative RA. Respiratory tract diseases tended towards higher associations in smokers, especially >10 packyears (OR 1.52, 95% CI:1.02,2.27; p=0.10 for interaction).

Thus, the researchers concluded that Acute/chronic sinusitis and pharyngitis and acute respiratory burden increased RA risk. The mucosal paradigm of RA pathogenesis may involve the upper respiratory tract.

Reference:

Association of sinusitis and upper respiratory tract diseases with incident rheumatoid arthritis: A case-control study by Vanessa L. Kronzer, et al. published in the Journal of Rheumatology.

https://www.jrheum.org/content/early/2021/10/10/jrheum.210580

sinusitiscommon coldrheumatoid arthritisrisk factorsupper respiratory tract infectionthe Journal of Rheumatology
Source : The Journal of Rheumatology
Dr. Shravani Dali
Dr. Shravani Dali

    Dr. Shravani Dali has completed her BDS from Pravara institute of medical sciences, loni. Following which she extensively worked in the healthcare sector for 2+ years. She has been actively involved in writing blogs in field of health and wellness. Currently she is pursuing her Masters of public health-health administration from Tata institute of social sciences. She can be contacted at editorial@medicaldialogues.in.

    Dr. Kamal Kant Kohli
    Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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