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  • Antenatal Fexofenadine ...

Antenatal Fexofenadine not linked to risk of abortion or premature birth

Dr. Kamal Kant KohliBy Dr. Kamal Kant KohliPublished On 2020-06-04T16:41:45+05:30  |  Updated On 2020-06-06T16:21:49+05:30
Antenatal Fexofenadine not linked to risk of abortion or premature birth

A new JAMA study has revealed that Fexofenadine use during pregnancy was not linked with birth defects or spontaneous abortion. Antihistamines are one of the most commonly prescribed drug classes during pregnancy. Fexofenadine hydrochloride is a widely used, nonsedating, second-generation antihistamine for treatment of allergic disorders, including seasonal rhinitis and chronic...

A new JAMA study has revealed that Fexofenadine use during pregnancy was not linked with birth defects or spontaneous abortion.

Antihistamines are one of the most commonly prescribed drug classes during pregnancy. Fexofenadine hydrochloride is a widely used, nonsedating, second-generation antihistamine for treatment of allergic disorders, including seasonal rhinitis and chronic idiopathic urticaria, estimated to affect 20% to 30% of women of childbearing age.

Fexofenadine hydrochloride is a frequently used drug for treatment of allergic conditions during pregnancy, but the fetal safety of fexofenadine use has not been well studied.

The researchers conducted a study to investigate the risk of adverse fetal outcomes associated with fexofenadine use during pregnancy.

The researchers conducted a nationwide registry-based cohort study on pregnancies in Denmark from January 1, 2001, to December 31, 2016. The data analysis was performed from March 21, 2019, to January 29, 2020. From a cohort of 1 287 668 pregnancies, fexofenadine use was compared with cetirizine hydrochloride use during pregnancy, matched in a 1:1 ratio on propensity scores. Distinct study cohorts and exposure time periods were applied according to each outcome analysis. Sensitivity analyses included comparing pregnancies with vs without fexofenadine exposure during pregnancy but with previous use before pregnancy and with loratadine use during pregnancy as additional comparator groups.

For the analyses of major birth defects and spontaneous abortion, a total of 2962 and 4901 pregnancies with fexofenadine use were included, respectively, matched in a 1:1 ratio with pregnancies with cetirizine use. Mean (SD) age of the fexofenadine cohort for analyses of major birth defects was 30.6 (4.8) years and, for analysis of spontaneous abortion, 30.4 (5.5) years. Infants born with major birth defects occurred in 118 pregnancies (4.0%) with fexofenadine use compared with 112 pregnancies (3.8%) with cetirizine use. Spontaneous abortion occurred in 413 pregnancies (8.4%) with fexofenadine use compared with 439 pregnancies (9.0%) with cetirizine use.

Fexofenadine use during pregnancy was not associated with an increased risk of major birth defects or spontaneous abortion compared with cetirizine use during pregnancy. Preterm birth occurred in 370 pregnancies (7.5%) with fexofenadine use compared with 382 pregnancies (7.7%) with cetirizine use (prevalence OR, 0.97; 95% CI, 0.83-1.12), SGA occurred in 515 pregnancies (10.1%) with fexofenadine use compared with 523 pregnancies (10.2%) with cetirizine use (prevalence OR, 0.98; 95% CI, 0.87-1.12), and a total of 16 pregnancies (0.3%) with fexofenadine use ended in stillbirth compared with 24 pregnancies (0.4%) with cetirizine use (HR, 0.67; 95% CI, 0.36-1.27). Sensitivity analyses of the primary outcomes, including the comparisons of pregnancies with loratadine use and pregnancies unexposed to fexofenadine during pregnancy but with prior use of fexofenadine, showed similar results.

The researchers concluded that use of fexofenadine during pregnancy does not appear to be associated with an increased risk of adverse fetal outcomes.No association was noted between fexofenadine use during pregnancy and risk of major birth defects, spontaneous abortion, preterm birth, small size for gestational age, or stillbirth.

For further reference log on to:

JAMA Pediatr. Published online June 1, 2020.

fexofenadine sntenatal premature birth birth defects spontaneous abortion risk 
Source : JAMA pediatrics
Dr. Kamal Kant Kohli
Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as an Editor-in-Chief for the Speciality Medical Dialogues section. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Before Joining Medical Dialogues, he has served at important positions in the medical industry in India including as the Hony. Secretary of the Delhi Medical Association as well as the chairman of Anti-Quackery Committee in Delhi and worked with other Medical Councils in India. Email: editorial@medicaldialogues.in. Contact no. 011-43720751

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