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  • Early-life exposure to...

Early-life exposure to smoking, indoor black carbon may accelerate aging: Study

Hina ZahidWritten by Hina Zahid Published On 2021-08-30T09:00:56+05:30  |  Updated On 30 Aug 2021 3:31 AM GMT
Early-life exposure to smoking, indoor black carbon may accelerate aging: Study
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Spain: Children exposed to tobacco smoke during pregnancy, their early childhood, and indoor black carbon may experience accelerated epigenetic aging from an early age, a recent study has revealed. The study, published in the journal Environment International, is the first to evaluate associations between a large number of early-life environmental exposures and epigenetic age in...

Spain: Children exposed to tobacco smoke during pregnancy, their early childhood, and indoor black carbon may experience accelerated epigenetic aging from an early age, a recent study has revealed. The study, published in the journal Environment International, is the first to evaluate associations between a large number of early-life environmental exposures and epigenetic age in children.

The association was established with more than 100 environmental exposures and the 'epigenetic clock' of over 1,000 children in six European countries.

"Aging is considered a public health issue worldwide. Considering this new evidence in children might drive new policies to reduce environmental exposure and promote healthy aging in their early life," wrote the authors. 

Exposure to environmental factors during pregnancy and early childhood can significantly – and sometimes irreversibly – alter our metabolism and physiology, thereby determining our health status later in life. It can also accelerate the process of biological aging, which has been associated with a higher risk of metabolic, cardiovascular, or neurodegenerative diseases. At the cellular level, aging is a continuous process that starts early in life, and which can be measured thanks to epigenetic clocks. Epigenetic clocks use the levels of DNA methylation in certain regions of the genome to infer the biological aging of a person.

"The epigenetic clock allows us to assess whether someone's biological age is older or younger than his or her chronological age," explains Mariona Bustamante, ISGlobal researcher and last author of the study. Several studies have shown an association between acceleration in epigenetic aging and certain environmental exposures, but most were performed in adults and focusing on single exposures. In this study, the team led by Bustamante investigated for the first time the association between the early-life exposome (83 prenatal exposures and 103 in early childhood) and the epigenetic age of 1,173 children between 6 and 11 years of age from the Human Early Life Exposome (HELIX) project, based on six birth cohorts in six European countries, including Spain, and coordinated by ISGlobal researcher Martine Vrijheid.

After selecting the best suited epigenetic clock for the study and adjusting for multiple factors, the research team found that exposure to maternal tobacco smoke during pregnancy was associated with an acceleration in epigenetic aging. Regarding the postnatal exposome, the analysis showed association with two exposures: parental smoking and indoors levels of black carbon, an air pollutant that results from the incomplete combustion of fuels (and is indirectly measured by particulate matter absorbance or PMabs).

Intriguingly, two other variables were associated with a slowing in biological aging: the organic pesticide DMDTP and a persistent organic pollutant (polychlorinated biphenyl-138). "Further research is needed to explain these results, but the former could be due to a higher intake of fruits and vegetables while the latter could be explained by its correlation with body mass index," says Paula de Prado-Bert, first author of the study.

"The positive association between epigenetic age acceleration and exposure to tobacco smoke during pregnancy and early childhood go in line with previous results obtained in the adult population," says Bustamante. The epigenetic modifications could affect pathways involved in inflammation, toxin elimination, and cell cycle, with a subsequent impact on health.

Admittedly, these associations do not prove causality, but this and future early life exposome studies will help guide health policies to reduce certain environmental exposures and promote a "healthy aging" from early life stages.

Reference:

The study titled, "The early-life exposome and epigenetic age acceleration in children," is published in the journal Environment International.

https://www.sciencedirect.com/science/article/pii/S0160412021003081


smokingtobacco smokeagingEnvironment International
Source : Environment International
Hina Zahid
Hina Zahid

    Hina Zahid Joined Medical Dialogue in 2017 with a passion to work as a Reporter. She coordinates with various national and international journals and association and covers all the stories related to Medical guidelines, Medical Journals, rare medical surgeries as well as all the updates in the medical field. Email: editorial@medicaldialogues.in. Contact no. 011-43720751

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