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  • Probiotics with...

Probiotics with laxatives improve functional constipation in children, Study Finds

Written By : Dr.Niharika Harsha B |Written By : Dr. Kamal Kant Kohli Published On 2024-12-19T00:30:31+05:30  |  Updated On 19 Dec 2024 12:44 PM IST
Probiotics with laxatives improve functional constipation in children, Study Finds
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A recent network meta-analysis conducted in Taiwan revealed that a combination of probiotics and laxatives reduces functional constipation in children, as published in the European Journal of Pediatrics.

Pediatric constipation is highly prevalent in Taiwan and ranges from 0.7 to 29.6% across different countries. Functional constipation is seen in about 95% of the pediatric population. However, the effect of pharmacotherapy is limited. The noted success rate is only 60%. Previous research has shown the benefits of probiotic supplements in treating this condition. There was uncertainty due to the varied strains of probiotics used in the study. Hence, Taiwanese researchers conducted a network meta-analysis to compare the efficacy and acceptability of different probiotic supplements for pediatric functional constipation.

Also Read: Biofeedback effectively improves functional defecation disorder symptoms, finds study

A frequentist model-based network meta-analysis (NMA) was carried out by including RCTs of probiotic supplements for functional constipation in children. Potentially eligible articles without any language restrictions were included in the study. PICO design was implemented and based on this clinical RCT with waiting lists, placebo or active controls were considered. Children less than 18 years of age with functional constipation were included. The efficacy of probiotics on stool frequency and bowel movements was investigated.

The objective outcome of bowel movement or stool frequency defined as the number of bowel movements/stool passages per fixed period was considered as the outcome of the study. STATA version 16.0 was used for NMA.

Findings:

  • Nine RCTs were included with about 710 participants having a mean age of 5.5 years. There were 49.4% girls.
  • A significant improvement in bowel movement or stool frequency was seen by using the probiotic products either alone or combined with laxatives than placebo or control.
  • The greatest improvement in bowel movement or stool frequency among all the investigated probiotic products was seen with Protexin plus laxatives.
  • Lactobacillus casei rhamnosus Lcr35 was the only probiotic associated with significant efficacy in single probiotic interventions, compared to placebo/control treatments.
  • The fecal incontinence and patient drop-out rates were similar among the investigated probiotic products to those of placebo/control treatments.
Also Read: Feeling Constipated? You May Have Higher Risk for Heart Disease, suggests study

Thus, the study concluded that most of the probiotics combined with laxatives have a better outcome for constipation. They produced significantly better improvement in bowel movement/stool frequency. Hence, researchers underscored the importance of using an advanced combination of probiotics and laxatives for pediatric functional constipation if there is no concurrent contraindication.

Further reading: Yang, WC., Zeng, BS., Liang, CS. et al. Efficacy and acceptability of different probiotic products plus laxatives for pediatric functional constipation: a network meta-analysis of randomized controlled trials. Eur J Pediatr 183, 3531–3541 (2024). https://doi.org/10.1007/s00431-024-05568-6.

European Journal of Pediatricsnetwork meta-analysisWei-Chieh Yangprobiotic productspediatric functional constipation
Source : European Journal of Pediatrics
Dr.Niharika Harsha B
Dr.Niharika Harsha B

    BDS, MDS

    Dr.Niharika Harsha B (BDS,MDS) completed her BDS from Govt Dental College, Hyderabad and MDS from Dr.NTR University of health sciences(Now Kaloji Rao University). She has 4 years of private dental practice and worked for 2 years as Consultant Oral Radiologist at a Dental Imaging Centre in Hyderabad. She worked as Research Assistant and scientific writer in the development of Oral Anti cancer screening device with her seniors. She has a deep intriguing wish in writing highly engaging, captivating and informative medical content for a wider audience. She can be contacted at editorial@medicaldialogues.in.

    Dr. Kamal Kant Kohli
    Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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