- Home
- Medical news & Guidelines
- Anesthesiology
- Cardiology and CTVS
- Critical Care
- Dentistry
- Dermatology
- Diabetes and Endocrinology
- ENT
- Gastroenterology
- Medicine
- Nephrology
- Neurology
- Obstretics-Gynaecology
- Oncology
- Ophthalmology
- Orthopaedics
- Pediatrics-Neonatology
- Psychiatry
- Pulmonology
- Radiology
- Surgery
- Urology
- Laboratory Medicine
- Diet
- Nursing
- Paramedical
- Physiotherapy
- Health news
- Fact Check
- Bone Health Fact Check
- Brain Health Fact Check
- Cancer Related Fact Check
- Child Care Fact Check
- Dental and oral health fact check
- Diabetes and metabolic health fact check
- Diet and Nutrition Fact Check
- Eye and ENT Care Fact Check
- Fitness fact check
- Gut health fact check
- Heart health fact check
- Kidney health fact check
- Medical education fact check
- Men's health fact check
- Respiratory fact check
- Skin and hair care fact check
- Vaccine and Immunization fact check
- Women's health fact check
- AYUSH
- State News
- Andaman and Nicobar Islands
- Andhra Pradesh
- Arunachal Pradesh
- Assam
- Bihar
- Chandigarh
- Chattisgarh
- Dadra and Nagar Haveli
- Daman and Diu
- Delhi
- Goa
- Gujarat
- Haryana
- Himachal Pradesh
- Jammu & Kashmir
- Jharkhand
- Karnataka
- Kerala
- Ladakh
- Lakshadweep
- Madhya Pradesh
- Maharashtra
- Manipur
- Meghalaya
- Mizoram
- Nagaland
- Odisha
- Puducherry
- Punjab
- Rajasthan
- Sikkim
- Tamil Nadu
- Telangana
- Tripura
- Uttar Pradesh
- Uttrakhand
- West Bengal
- Medical Education
- Industry
Stimulating nucleus accumbens remarkably improves Refractory Anorexia Nervosa, a case report
A case study published by Isabel Arroteia et al in British Medical Journal (BMJ), reports a case of 42yr-old women suffering from refractory chronic AN of bulimic sub-type for which DBS was found to be extremely effective.
AN takes a chronic course in up to 21% of patients and does not respond to conventional treatment options. This form is associated with critical metabolic, endocrine, and electrolyte imbalance as well as psychiatric comorbidities. The serious course of the disease in the most severely affected patients justifies invasive treatment options like deep brain stimulation.
Midbrain/ventral tegmental area, ventral striatum (including the nucleus accumbens (NAcc), medial frontal and orbitofrontal cortex make the reward system of brain which is believed to be dysfunctional in AN. The neurocircuitry involved in AN is believed to overlap the one involved in obsessive-compulsive disorder (OCD). As deep brain stimulation (DBS) of the NAcc has efficacy in OCD, the NAcc might also be an effective DBS target in patients with chronic AN.
A 42-years-old woman suffering from chronic AN of the bulimic subtype presented with severe AN. The severity of the disease has increased over the years and eventually led to comorbid depression. At the time of presentation, the patient weighed only 32 kg (BMI) 12.8 kg/m2 and was compulsively binge eating and purging several times a day. Concurrent metabolic and endocrine disturbances had led to amenorrhea and osteoporosis with severe leucopenia that led to repeated life-threatening infections. The patient had participated in various psychiatric therapies, including behavioral therapy. None of these were able to provide lasting relief of symptoms or weight gain. The patient was then referred to the neurosurgery department for DBS implantation.
The surgery was uneventful. After the surgery, the patient did not show any new neurological deficits, and wound healing was regular. The postoperative location of DBS electrodes was determined computationally, as shown in figure 1. In-patient psychiatric follow-up was organised.
The first neurosurgical follow-up appointment took place 1 month later. Over the ensuing 12 months patient showed consistent weight gain (as shown in the graph) and a decrease in the frequency of binge eating and purging.
As the skin conditions were very atrophic, the patient developed a 1×1 cm large ulceration of the skin over the fixation cap of the left DBS electrode. After a long discussion with the patient, it was decided to continue with a close follow-up. At this point, the patient's menstrual cycle had already normalized.
After 14 months of follow-up, her weight was stable, but she presented with an increase in the frequency of binge eating and purging over the previous months. Stimulation parameters were reduced. The wound over the left burr hole cap remained unchanged. Stimulation parameters were gradually increased in the following months. As the symptoms persisted, at 19 months of follow-up the patient asked for the stimulation to be turned off.
At 24 months of follow-up, a total weight gain of 10 kg was seen.
Six weeks later, the patient had lost an additional 3 kg of weight and suffered from the persistence of bingeing and purging, with the stimulation still turned off at that point. The patient was then admitted to the emergency room with headaches and signs of infection over the subcutaneous trajectory of the cables and the wound over the left burr hole cap and was treated for same. The explantation of the DBS system was performed as soon as possible.
The authors concluded that if the patient's life is at risk, there is a potential indication for NAcc DBS when conventional treatment modalities recommended by evidence-based guidelines have not been able to durably alleviate the patient's suffering.
Source: BMJ case reports: Fernandes Arroteia I, et al. BMJ Case Rep 2020;13:e239316. doi:10.1136/bcr-2020-239316
M.B.B.S, M.D. Psychiatry
M.B.B.S, M.D. Psychiatry (Teerthanker Mahavir University, U.P.) Currently working as Senior Resident in Department of Psychiatry, Institute of Human Behaviour and Allied Sciences (IHBAS) Dilshad Garden, New Delhi. Actively involved in various research activities of the department.
Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751