- Home
- Medical news & Guidelines
- Anesthesiology
- Cardiology and CTVS
- Critical Care
- Dentistry
- Dermatology
- Diabetes and Endocrinology
- ENT
- Gastroenterology
- Medicine
- Nephrology
- Neurology
- Obstretics-Gynaecology
- Oncology
- Ophthalmology
- Orthopaedics
- Pediatrics-Neonatology
- Psychiatry
- Pulmonology
- Radiology
- Surgery
- Urology
- Laboratory Medicine
- Diet
- Nursing
- Paramedical
- Physiotherapy
- Health news
- Fact Check
- Bone Health Fact Check
- Brain Health Fact Check
- Cancer Related Fact Check
- Child Care Fact Check
- Dental and oral health fact check
- Diabetes and metabolic health fact check
- Diet and Nutrition Fact Check
- Eye and ENT Care Fact Check
- Fitness fact check
- Gut health fact check
- Heart health fact check
- Kidney health fact check
- Medical education fact check
- Men's health fact check
- Respiratory fact check
- Skin and hair care fact check
- Vaccine and Immunization fact check
- Women's health fact check
- AYUSH
- State News
- Andaman and Nicobar Islands
- Andhra Pradesh
- Arunachal Pradesh
- Assam
- Bihar
- Chandigarh
- Chattisgarh
- Dadra and Nagar Haveli
- Daman and Diu
- Delhi
- Goa
- Gujarat
- Haryana
- Himachal Pradesh
- Jammu & Kashmir
- Jharkhand
- Karnataka
- Kerala
- Ladakh
- Lakshadweep
- Madhya Pradesh
- Maharashtra
- Manipur
- Meghalaya
- Mizoram
- Nagaland
- Odisha
- Puducherry
- Punjab
- Rajasthan
- Sikkim
- Tamil Nadu
- Telangana
- Tripura
- Uttar Pradesh
- Uttrakhand
- West Bengal
- Medical Education
- Industry
5-ARIs use not linked to dementia risk but associated with depression: JAMA
Sweden: Users of 5-ARIs (5a-reductase inhibitors) and prescribing clinicians should be aware of the possible depression risks associated with its use, researchers warn in a research published in JAMA Network Open.
The study showed that men receiving 5-ARIs for androgenic alopecia and benign prostatic hyperplasia (BPH) had a greater dementia risk in the initial period after treatment initiation; however, the magnitude of the association decreased over time. This suggested that the risk may be entirely or partly due to the increased detection of dementia in patients with benign prostate enlargement. Dutasteride and finasteride were shown to be similarly associated with depression with a constant risk over time, while neither drug was linked with suicide.
There has been an increasing interest in the possible adverse neurological effects of 5-ARIs in recent decades, which have been used mainly for androgenic alopecia and benign prostatic hyperplasia. Several studies and reports have suggested associations of 5-ARIs with suicide and depression. However, most of these studies had methodological shortcomings, and little is known about the potential associations of 5-ARIs with dementia.
Against the above background, Miguel Garcia-Argibay from Örebro University in Örebro, Sweden, and the team aimed to investigate the association of 5-ARI use with Alzheimer's disease, all-cause dementia, depression, vascular dementia, and suicide in a Swedish register-based cohort study.
A recorded prescription in the Swedish national prescription register of dutasteride or finasteride and duration of use. The study included 2 236 876 men aged 50 to 90 between 2005 and 2018. The study's primary outcomes were a diagnosis of Alzheimer's disease, all-cause dementia, depression, vascular dementia, or completed suicide.
The authors reported the following findings:
- Of 2 236 876 men (median age at the start of follow-up, 55 years and treatment initiation, 73 years), 3.2% (n=70 645) started finasteride treatment, and 0.4% (n=8774) started dutasteride treatment.
- Men taking finasteride or dutasteride were at increased risk of all-cause dementia (finasteride: hazard ratio [HR], 1.22; dutasteride: HR, 1.10), Alzheimer's disease (finasteride: HR, 1.20; dutasteride: HR, 1.28), vascular dementia (finasteride: HR, 1.44; dutasteride: HR, 1.31), and depression (finasteride: HR, 1.61; dutasteride: HR, 1.68).
- The magnitude of the association decreased over time, and the findings became statistically nonsignificant with continuous exposures over four years, except for depression, which showed a constant risk over time, with no differences between finasteride and dutasteride.
- 5-ARIs was not associated with suicide (finasteride: HR, 1.22; dutasteride: HR, 0.98).
"The results of this cohort study suggest that provided the decreasing magnitude of the association over time, 5-ARI medications—dutasteride and finasteride —do not seem to be associated with all-cause dementia, vascular dementia, Alzheimer's disease, or suicide," the researchers wrote. "However, individuals receiving 5-ARI treatment may be at increased depression risk."
Reference:
Garcia-Argibay M, Hiyoshi A, Fall K, Montgomery S. Association of 5α-Reductase Inhibitors With Dementia, Depression, and Suicide. JAMA Netw Open. 2022;5(12):e2248135. doi:10.1001/jamanetworkopen.2022.48135
MSc. Biotechnology
Medha Baranwal joined Medical Dialogues as an Editor in 2018 for Speciality Medical Dialogues. She covers several medical specialties including Cardiac Sciences, Dentistry, Diabetes and Endo, Diagnostics, ENT, Gastroenterology, Neurosciences, and Radiology. She has completed her Bachelors in Biomedical Sciences from DU and then pursued Masters in Biotechnology from Amity University. She has a working experience of 5 years in the field of medical research writing, scientific writing, content writing, and content management. She can be contacted at editorial@medicaldialogues.in. Contact no. 011-43720751
Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751