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  • New data supports an...

New data supports an association of depression with triglyceride glucose index among adults

Written By : Dr. Shivi Kataria |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2023-11-06T03:00:15+05:30  |  Updated On 6 Nov 2023 3:00 AM IST
New data supports an association of depression with triglyceride glucose index among adults
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China: A recent study published in Medicine has revealed an association between depression and triglyceride glucose (TyG) index. Thus, insulin resistance (IR) appears to be a risk factor for depression.

Major depressive disorder (MDD) is a common mental illness that has impacted human health and garnered widespread global attention. According to the WHO, depression will become the world’s leading health problem by 2030. However, existing antidepressants were developed based on the monoamine neurotransmitter hypothesis, and are not always clinically effective, showing a clinical response rate of <70%. Therefore, it is urgent to discover the pathogenesis of depression and possible therapeutic targets.

The TyG index can be used for IR assessment. The index is based on fasting triglyceride (TG) levels and glucose rather than glucose and insulin. TyG is suggested to be more convenient for clinical use and is an inexpensive and reliable alternative test for IR estimation. Previous studies have indicated interactions between insulin resistance and depression.

Against the above background, Peiyuan Lv, Department of Neurology, Hebei Medical University, Shijiazhuang, China, and colleagues investigated the association between the TyG index and depression to evaluate the presence of insulin resistance in depression. They also determined whether there is a difference between depressed patients and healthy controls.

The study included 198 middle-aged and elderly patients who were admitted to the Hebei General Hospital between 2021 and 2022, together with 189 healthy adults as controls. Depression diagnosis was done according to ICD-10 diagnostic criteria for depression. Insulin resistance was assessed by the TyG index.

The study led to the following findings:

  • Compared with the control group, patients suffering from depression had a higher TyG index.
  • There were significant differences in the sex ratio, body mass index, family history, total cholesterol, high-density lipoprotein, fasting blood glucose, and low-density lipoprotein levels between the two groups.
  • After excluding other confounding factors, the TyG index was found to be independently associated with depression, with an OR of 2.75.

"Our results suggest that there was a correlation between the TyG index and depression in elderly adults," the researchers wrote. "The TyG index was revealed to be higher in elderly patients with major depressive disorder than in the healthy controls."

The limitation of the study was its cross-sectional nature due to which the causal relationship between IR and depression could not be determined and changes in IR following antidepressant treatment were not analyzed and researchers suggest that it should be investigated in future studies.

Reference:

Zhang, Shipan MDa,b,c; Hou, Zhaowei MDd; Fei, Di MDb; Zhang, Xueru MDb; Gao, Chenyang MDb; Liu, Jing MDb; Jin, Man MDa,b,c; Zhai, Xiaoyan MDa,b; Zhou, Yaqing MD, PhDe; Ni, Aihua MDb; Lv, Peiyuan MD, PhDa,b,c,*. Associations between triglyceride glucose index and depression in middle-aged and elderly adults: A cross-sectional study. Medicine 102(43):p e35530, October 27, 2023. | DOI: 10.1097/MD.0000000000035530


Medicinemajor depressive disordertriglyceride glucose indexdepressioninsulin resistance
Source : Medicine
Dr. Shivi Kataria
Dr. Shivi Kataria

    M.B.B.S, M.D. Psychiatry

    M.B.B.S, M.D. Psychiatry (Teerthanker Mahavir University, U.P.) Currently working as Senior Resident in Department of Psychiatry, Institute of Human Behaviour and Allied Sciences (IHBAS) Dilshad Garden, New Delhi. Actively involved in various research activities of the department.

    Dr. Kamal Kant Kohli
    Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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