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Patients with major depressive disorder may have significantly high Triglyceride levels and CVD risk: Study

Written By : Jacinthlyn Sylvia |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2024-10-27T21:00:11+05:30  |  Updated On 28 Oct 2024 2:54 PM IST
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A new study published in the journal of Public Library of Science found that the triglyceride levels of individuals with major depressive disorder (MDD) were markedly higher. Cardiovascular disease is more common in those who are depressed. Young individuals who self-reported feeling melancholy or having bad mental health days had higher rates of strokes, heart attacks, and heart disease risk factors than their counterparts without mental health concerns. According to literature, this can be the case since sadness can promote hazardous lifestyle choices including smoking, consuming alcohol, sleeping less, and not exercising, as well as an increase in blood pressure and heart rate.

Triglycerides are thought to be a risk factor in and of itself for atherosclerosis, which causes myocardial infarction and ischemic stroke. This research hypothesized that there is a substantial change in triglyceride levels in patients with depression when compared to healthy controls. Since a previous study revealed that lipid metabolites might vary between patients with severe depressive disorder and healthy participants. To evaluate peripheral blood triglyceride levels between MDD patients and healthy controls, Di-Ru Xu and team made the decision to carry out a new study.

Until March 2023, the studies were searched in the Cochrane, EMBASE, PsycINFO, and PubMed databases. The standardized mean difference (SMD) was calculated by extracting the mean (±SD) for TG concentrations and combining them quantitatively using random-effects meta-analysis. Meta-regression and subgroup analysis were used to investigate the heterogeneity resource.

38 studies that measured peripheral blood TG concentrations in 3272 HCs and 2604 MDD patients were included. According to the findings of the meta-analysis, the patients with MDD had significantly higher TG levels than HCs. There was evidence of heterogeneity (χ2 = 269.97, p < 0.01, I2 = 85%). Subgroup analysis revealed that there were no differences across groups, although there were significant variations in TG levels between patients with MDD and HCs based on age, body mass index, and medication usage (p < 0.05). Additionally, meta-regression revealed no significant factors. Overall, these results point to the need to measure the possible advantages of a low-triglyceride diet in MDD patients and look into the possible roles of triglycerides in the pathophysiology of depression.

Source:

Xu, D.-R., Gao, X., Zhao, L.-B., Liu, S.-D., Tang, G., Zhou, C.-J., & Chen, Y. (2024). Association between triglyceride and depression: A systematic review and meta-analysis. In Md. R. Islam (Ed.), PLOS ONE (Vol. 19, Issue 10, p. e0311625). Public Library of Science (PLoS). https://doi.org/10.1371/journal.pone.0311625

PLOS ONE Journaltriglyceride levelmajor depressive disorder
Source : Public Library of Science
Jacinthlyn Sylvia
Jacinthlyn Sylvia

    Neuroscience Masters graduate

    Jacinthlyn Sylvia, a Neuroscience Master's graduate from Chennai has worked extensively in deciphering the neurobiology of cognition and motor control in aging. She also has spread-out exposure to Neurosurgery from her Bachelor’s. She is currently involved in active Neuro-Oncology research. She is an upcoming neuroscientist with a fiery passion for writing. Her news cover at Medical Dialogues feature recent discoveries and updates from the healthcare and biomedical research fields. She can be reached at editorial@medicaldialogues.in

    Dr. Kamal Kant Kohli
    Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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