People with anxiety and depression are more prone to develop alcohol use disorder symptoms

UK: Individuals with anxiety or major depressive disorder experience more alcohol-related symptoms than people without those disorders who drink at the same level, new research has shown.

The finding, published in the journal Alcohol: Clinical & Experimental Research, might help to explain why those who develop an anxiety or mood disorder are at heightened risk of alcohol use disorder (AUD), which is characterized by uncontrolled drinking and preoccupation with alcohol.

“Our findings show that on a drink-for-drink basis, those with anxiety and depression experience more symptoms related to alcohol use disorder. If addiction were a competition, those with anxiety and depression would have a significant head start,” said Matt Kushner, PhD, a professor at the U of M Medical School.

Internalizing disorders-like anxiety disorder or a major depressive disorder-commonly co-occur with AUD. Approximately 20-40% of people with an internalizing disorder have AUD, compared to 5% of the general population. Previous studies have shown people with internalizing disorders become dependent on alcohol more quickly than others, even at similar levels of use.

In this study, the research team analyzed data on 26,000 adults from the National Epidemiological Survey on Alcohol Related Conditions and compared AUD-related symptoms in people with an internalizing disorder and those without, accounting for alcohol intake and other factors.

The study found anxiety disorder and major depressive disorder predicted more alcohol-related symptoms-even when level of drinking is held constant. This is an example of the ‘harm paradox’ effect-or the negative consequences from a given level of substance use within a certain group that exceed those experienced by people outside that group.

Other key findings from this study include:

• The harm paradox effect was evident not only for those whose anxiety and depression disorders were ongoing, but also for those who had these mental conditions in the past only.

• The harm paradox effect was even more pronounced for those with more than one anxiety or depression disorder.

• The harm paradox effect was equally evident in both men and women with an anxiety or depression disorder.

Although this study didn’t directly evaluate neurobiological processes, the findings are consistent with the view that addiction and anxiety/depression disorders share some of the same biological processes in the brain. This may help explain why one of these conditions is a risk factor for developing the other in the future.

Future research is needed to confirm the role of neurobiological mechanisms underlying the harm paradox. Additionally, prospective studies - following the same people over a period of years - would allow for a more refined understanding of the harm paradox identified in this study. Finally, the research team says policymakers should consider whether the harm paradox warrants more restrictive recommendations regarding ‘safe’ levels of alcohol use for those with anxiety and depression disorders.

Reference:

Justin J. Anker, Paul Thuras, Ruichong Shuai, Lee Hogarth, Matt G. Kushne, Evidence for an alcohol-related “harm paradox” in individuals with internalizing disorders: Test and replication in two independent community samples, Published: 28 April 2023, https://doi.org/10.1111/acer.15036.