AI model used with one-inhale CT helps diagnose COPD: Study

A study measured the benefit of single-phase CT, inspiratory-expiratory CT, and clinical data for convolutional neural network (CNN)–based chronic obstructive pulmonary disease (COPD) staging.

This retrospective study included inspiratory and expiratory lung CT images and spirometry measurements acquired between November 2007 and April 2011 from 8893 participants (mean age, 59.6 years ± 9.0 [SD]; 53.3% [4738 of 8893] male) in the COPDGene phase I cohort (ClinicalTrials.gov: NCT00608764). CNNs were trained to predict spirometry measurements (forced expiratory volume in 1 second [FEV1], FEV1 percent predicted, and ratio of FEV1 to forced vital capacity [FEV1/FVC]) using clinical data and either single-phase or multiphase CT. Spirometry predictions were then used to predict Global Initiative for Chronic Obstructive Lung Disease (GOLD) stage.

Agreement between CNN-predicted and reference standard spirometry measurements and GOLD stage was assessed using intraclass correlation coefficient (ICC) and compared using bootstrapping. Accuracy for predicting GOLD stage, within-one GOLD stage, and GOLD 0 versus 1–4 was calculated.

Results: CNN-predicted and reference standard spirometry measurements showed moderate to good agreement (ICC, 0.66–0.79), which improved by inclusion of clinical data (ICC, 0.70–0.85; P ≤ .04), except for FEV1/FVC in the inspiratory-phase CNN model with clinical data (P = .35) and FEV1 in the expiratory-phase CNN model with clinical data (P = .33). Single-phase CNN accuracies for GOLD stage, within-one stage, and diagnosis ranged from 59.8% to 84.1% (682–959 of 1140), with moderate to good agreement (ICC, 0.68–0.70).

Accuracies of CNN models using inspiratory and expiratory images ranged from 60.0% to 86.3% (684–984 of 1140), with moderate to good agreement (ICC, 0.72). Inclusion of clinical data improved agreement and accuracy for both the single-phase CNNs (ICC, 0.72; P ≤ .001; accuracy, 65.2%–85.8% [743–978 of 1140]) and inspiratory-expiratory CNNs (ICC, 0.77–0.78; P ≤ .001; accuracy, 67.6%–88.0% [771–1003 of 1140]), except expiratory CNN with clinical data (no change in GOLD stage ICC; P = .08). CNN-based COPD diagnosis and staging using single-phase CT provides comparable accuracy with inspiratory-expiratory CT when provided clinical data relevant to staging.

Reference:

Evaluating the Cumulative Benefit of Inspiratory CT, Expiratory CT, and Clinical Data for COPD Diagnosis and Staging through Deep Learning, Amanda N. Lee, Albert Hsiao, Kyle A. Hasenstab. Author Affiliations. Published Online:Dec 12 2024https://doi.org/10.1148/ryct.240005