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  • Azithromycin may...

Azithromycin may improve asthma control in kids by reducing exacerbations

Written By : Medical Dialogues Editorial Team |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2022-03-14T09:00:29+05:30  |  Updated On 14 March 2022 9:01 AM IST
Azithromycin may improve asthma control in kids by reducing exacerbations
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New Delhi: The administration of azithromycin to children having poorly controlled asthma resulted in better asthma control and fewer exacerbations, says an article published in CHEST Journal, on 21st February 2022.

Azithromycin has immunomodulatory properties, and it has been shown to be useful in asthmatic adults. There is a scarcity of data about children. As a result, Jagat Jeevan Ghimire and colleagues undertook this trial to determine if adding oral azithromycin (I) to conventional medication (C) in children with poorly controlled asthma (P) improves asthma control (O) when compared to standard treatment alone.

This open-label controlled randomized study recruited children (5-15 years old) with poorly controlled asthma as determined by a score of 19 on the asthma control test (ACT)/childhood asthma control test (CACT). They were randomly assigned to either conventional therapy or azithromycin (10 mg/kg/dose) three times a week for three months. At three months, the primary outcome was the ACT/CACT score. Secondary outcomes were asthma management according to GINA standards, the frequency of exacerbations, changes in spirometry parameters, changes in FeNO, positive throat swab results, and side effects.

The results of this stated as follow:

1. The study included 120 children (89 boys) (60 in each group). The average age was 9.9 years.

2. The groups' baseline parameters were comparable. At three months of intervention, the mean (SD) ACT/CACT score (available for 115 children) was [21.71 (2.17) vs 18.33 (2.19)] in the azithromycin and control groups, respectively.

3. According to GINA recommendations, the number of children with well-controlled asthma was 41/56 versus 10/56 in the azithromycin and control groups, respectively.

4. The azithromycin group had a lower median (IQR) number of exacerbations necessitating an emergency visit and steroid treatment [0 (3) vs. 1 (6); p-value 0.001].

5. There was no difference between the groups in terms of FeNO, spirometry parameters, throat swab positive, or side effects.

In conclusion, when compared to standard therapy alone, the addition of oral azithromycin to standard treatment improved asthma control and reduced exacerbations in children with poorly controlled asthma.

Reference:

Ghimire, J. J., Jat, K. R., Sankar, J., Lodha, R., Iyer, V. K., Gautam, H., Sood, S., & Kabra, S. K. (2022). Azithromycin for Poorly Controlled Asthma in Children: A randomized controlled trial. Chest, S0012-3692(22)00293-8. Advance online publication. https://doi.org/10.1016/j.chest.2022.02.025

Keywords: throat swab, azithromycin, asthma, pediatrics, exacerbations, pulmonary function, antibiotics, asthma control, asthma in children, chest journal, poorly controlled asthma

azithromycinasthma in chidrenCHEST journalAsthma exacerbations
Source : CHEST Journal
Medical Dialogues Editorial Team
Medical Dialogues Editorial Team

    Medical Dialogues consists of a team of passionate medical/scientific writers, led by doctors and healthcare researchers. Our team efforts to bring you updated and timely news about the important happenings of the medical and healthcare sector. Our editorial team can be reached at editorial@medicaldialogues.in.

    Dr. Kamal Kant Kohli
    Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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