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  • Better Lung Function...

Better Lung Function Linked to Lower Risk of Cardiometabolic Diseases, finds study

Written By : Dr Riya Dave |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2025-02-03T20:30:09+05:30  |  Updated On 4 Feb 2025 3:14 PM IST
Better Lung Function Linked to Lower Risk of Cardiometabolic Diseases, finds study
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Researchers have found in a new study that Individuals with better lung function, as measured by forced vital capacity (FVC), were less likely to develop diabetes, heart disease, and stroke over a 10-year period. This study was conducted by Christer J. and colleagues published in the journal BMJ Open Respiratory Research. Earlier research conducted in developed countries showed an association between greater FVC levels and lower incidences of those diseases.

The study recruited data from 5916 participants in the Burden of Obstructive Lung Disease (BOLD) project. Baseline measurements for spirometry measures include postbronchodilator FEV1, FVC, and FEV1/FVC, with a follow-up to ascertain new events such as hypertension, diabetes, heart disease, and stroke. The new cases were defined as participants who reported a diagnosis of these diseases at follow-up but not at baseline. Data from each site were analyzed using regression models, and findings were pooled through random-effects meta-analysis. Adjustments were made for age, sex, smoking status, body mass index (BMI), and education level.

Results

• The mean follow-up period was 9.5 ± 3.6 years.

• Lower FVC and disease incidence: Participants who were 10% higher in the predicted FVC showed significantly lesser likelihood of having

• Diabetes (Odds Ratio [OR]: 0.91, 95% CI: 0.84 to 0.99)

• Heart disease (OR: 0.86, 95% CI: 0.80 to 0.92)

• Stroke (OR: 0.81, 95% CI: 0.73 to 0.89)

• FEV1 relation: High FEV1 had an inverse relationship with risk factors for heart disease and stroke.

• FEV1/FVC and diabetes: Interestingly, a greater FEV1/FVC ratio was associated with an increased risk of diabetes (OR per 10% = 1.21, 95% CI: 1.08 to 1.35).

• FEV1/FVC unrelated to other diseases: There were no significant associations between FEV1/FVC and the occurrence of heart disease or stroke.

Low FVC emerged as a critical determinant of cardiometabolic disease risk, suggesting its inclusion in predictive models could improve early detection and management strategies. This study offers robust evidence supporting the role of lung function as a broader indicator of systemic health and calls for further research into its integration into clinical risk assessments.

Reference:

Janson, C., Potts, J., Malinovschi, A., Agarwal, D., Ahmed, R., Aquart-Stewart, A., Harrabi, I., Denguezli, M., Devereux, G., Erhabor, G. E., Gislason, T., Jogi, R., Juvekar, S. K., Knox-Brown, B., Koul, P., Mortimer, K., Nafees, A. A., Nielsen, R., Mahesh, P. A., … Amaral, A. F. S. (2025). Lung function and onset of cardiometabolic diseases in the longitudinal Burden of Obstructive Lung Disease study. BMJ Open Respiratory Research, 12(1), e002442.https://doi.org/10.1136/bmjresp-2024-002442

BMJ Open Respiratory ResearchLung functionForced vital capacityCardiometabolic diseasesDiabetesHeart diseaseStrokeSpirometryRisk prediction
Source : BMJ Open Respiratory Research
Dr Riya Dave
Dr Riya Dave

    Dr Riya Dave has completed dentistry from Gujarat University in 2022. She is a dentist and accomplished medical and scientific writer known for her commitment to bridging the gap between clinical expertise and accessible healthcare information. She has been actively involved in writing blogs related to health and wellness.

    Dr. Kamal Kant Kohli
    Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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