Chronic rhinosinusitis risk closely connected with frailty, slowness and emotional tiredness: Study

A new study published in the journal of The Laryngoscope showed that, there is a connection between frailty and chronic rhinosinusitis (CRS), which may be brought on by emotional tiredness and slowness. This suggests that in order to control the occurrence of CRS, effective therapies for avoiding frailty should be created.

One of the most prevalent chronic illnesses affecting people in the US is chronic rhinosinusitis (CRS), which is characterized by symptoms of inflammation of the sinonasal mucosa that last for at least 12 weeks. Chronic rhinosinusitis without nasal polyposis (CRSsNP) and chronic rhinosinusitis with nasal polyposis (CRSwNP) are the two distinct phenotypes into which CRS is usually clinically divided. With disease-specific costs of almost $6 billion a year, patients with CRS experience a markedly reduced quality of life, including diminished health usefulness, mental anguish, and decreased physical and social activities. Despite ongoing research into the pathophysiology of CRS, the etiology of the condition is still up for debate. In this study, Han Chen and team used a representative sample from the Korean population to examine the relationship between chronic rhinosinusitis and frailty.

A total of 24,269 people participated in this cross-sectional study at first, and the Korean National Health and Nutrition Examination Survey (KNHANES) database provided the data. Using criteria specifically designed for the KNHANES dataset, the modified frailty phenotype (FP) and frailty index (FI) were used to measure frailty. The self-reported medical histories of participants were used to identify CRS. To investigate the relationship between CRS and frailty, univariate and multivariate logistic regression models were used.

When compared to the non-frail group, the prevalence of CRS was greater in the frail group. An increased risk of CRS was linked to both frailty status (as determined by FP) and frailty status (as determined by FI), especially in the ones who were 40 to 60 years old and ≥61 years old, as well as the ones with less than a high school diploma. Increased slowness and emotional tiredness may be the cause of the elevated risk of CRS linked to frailty.

Overall, the modified frailty phenotype (FP) and frailty index (FI), which measure frailty, both significantly correlate with the increased frequency of chronic rhinosinusitis in frail people. The ones with less education and those aged 40 to 60 and ≥61 were at a higher risk. CRS risk was significantly influenced by slowness and emotional tiredness.

Source:

Chen, H., Wang, L., Zhang, J., Yan, X., Yu, L., & Jiang, Y. (2024). Frailty as a Risk Factor for Chronic Sinusitis: Insights from a Nationwide Cross‐sectional Survey. In The Laryngoscope. Wiley. https://doi.org/10.1002/lary.31924