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  • Corticosteroids halt...

Corticosteroids halt progression of community acquired pneumonia to mechanical ventilation

Written By : Dr. Shravani Dali |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2022-09-28T09:30:52+05:30  |  Updated On 28 Sept 2022 3:01 PM IST
Corticosteroids halt progression of community acquired pneumonia to mechanical ventilation
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Corticosteroids prevent mechanical ventilation in Pneumonia according to a recent study published in the Chest.

Community-acquired pneumonia (CAP) is a leading cause of morbidity and mortality. Corticosteroids may be a beneficial adjunct in the treatment of bacterial pneumonia.

PubMed, Cochrane Library and Embase were searched to identify randomized control trials (RCTs) assessing the use of systemic corticosteroids compared to standard care in the management of CAP. A systematic review, meta-analysis, and trial sequential analysis (TSA) were performed. The primary outcome was all-cause mortality. Secondary outcomes included intensive care unit admission, mechanical ventilation, treatment failure, readmission, and adverse events. Data are presented as relative risk (confidence intervals), p-value, heterogeneity (I2) and TSA-adjusted confidence intervals.

Results:

  • Sixteen trials met the eligibility criteria. All-cause mortality, ICU admission, treatment failure and the incidence of adverse events were similar between patients receiving corticosteroids and patients assigned to the control group.
  • The need for mechanical ventilation was lower among patients receiving corticosteroids compared to standard care.
  • However, corticosteroid use might be associated with higher rates of hospital readmission

Corticosteroid therapy is associated with a lower incidence of progression to requiring mechanical ventilation among patients hospitalized with CAP. There was no association between corticosteroid therapy and mortality, treatment failure, or adverse events.

Reference:

Saleem N, Kulkarni A, Chandos Snow TA, Ambler G, Singer M, Arulkumaran N. Effect of corticosteroids on mortality and clinical cure in community-acquired pneumonia: A systematic review, meta-analysis, and meta-regression of randomized control trials. Chest. 2022 Sep 7:S0012-3692(22)03705-9. doi: 10.1016/j.chest.2022.08.2229. Epub ahead of print. PMID: 36087797

ChestBacterial pneumoniacommunity-acquired pneumoniacorticosteroidsmeta-analysissteroid
Source : Chest
Dr. Shravani Dali
Dr. Shravani Dali

    Dr. Shravani Dali has completed her BDS from Pravara institute of medical sciences, loni. Following which she extensively worked in the healthcare sector for 2+ years. She has been actively involved in writing blogs in field of health and wellness. Currently she is pursuing her Masters of public health-health administration from Tata institute of social sciences. She can be contacted at editorial@medicaldialogues.in.

    Dr. Kamal Kant Kohli
    Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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