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  • Dextromethorphan May...

Dextromethorphan May Reduce Coughing During Bronchoscopy

Written By : Aditi |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2023-05-17T11:00:11+05:30  |  Updated On 17 May 2023 1:15 PM IST
Dextromethorphan May Reduce Coughing During Bronchoscopy
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India: A study published in Respirology has investigated dextromethorphan as a potential cough suppressant used before flexible bronchoscopy. Dextromethorphan premedication may have an additive effect on cough suppression, according to researchers from the Department of Pulmonary Medicine & Critical Care, All India Institute of Medical Sciences, Bhubaneswar.

Flexible bronchoscopy is a diagnostic procedure used for visualisation of airways and lungs. Despite sedation and topical anaesthetics, cough is encountered invariably and remains a persistent challenge.

There needs to be more research and data related to ideal cough suppressants which could be used during flexible bronchoscopy.

Considering the above background, researchers in the present study determined the role of dextromethorphan premedication in relieving the cough during flexible bronchoscopy. They did a single-centre study including patients aged ≥18 years.

These patients received dextromethorphan syrup 30 ml (90 mg) or an equal volume of placebo one h before the procedure.

A visual analogue scale was used for rating cough severity and discomfort at the end of the procedure. Bronchoscopists also rated cough severity.

The study results are:

  • A total of 112 patients were screened.
  • Ninety-four patients with a mean age of 51 were randomized to either the dextromethorphan or placebo groups.
  • Both groups had 47 patients each.
  • The patients-rated median cough scores were 15 mm in dextromethorphan versus 20 mm in placebo groups reported at the end of the procedure.
  • There were similarities in Patients-rated median cough scores at one h, discomfort scores and midazolam and lignocaine usage between the two groups.
  • The bronchoscopist-rated median cough score was lower in the intervention than in the placebo groups.

Concluding further, they wrote one hour before flexible bronchoscopy, Dextromethorphan premedication has an additive effect on cough suppression under conscious sedation and topical lignocaine.

“Further trials are needed to reiterate our findings with certainty”, they mentioned.

Further reading:

Dextromethorphan premedication alleviates cough during flexible bronchoscopy in adults: A randomized, double-blind placebo-controlled trial.

https://onlinelibrary.wiley.com/doi/10.1111/resp.14445


dextromethorphancoughingbronchoscopyRespirology Journalcough suppressantflexible bronchoscopy
Source : Respirology
Aditi
Aditi

    BDS, MDS in Periodontics and Implantology

    Dr. Aditi Yadav is a BDS, MDS in Periodontics and Implantology. She has a clinical experience of 5 years as a laser dental surgeon. She also has a Diploma in clinical research and pharmacovigilance and is a Certified data scientist. She is currently working as a content developer in e-health services. Dr. Yadav has a keen interest in Medical Journalism and is actively involved in Medical Research writing.

    Dr. Kamal Kant Kohli
    Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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