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  • Diaphragm Dysfunction...

Diaphragm Dysfunction Is Common in Asthma and Linked to Disease Severity, finds study

Written By : Dr Riya Dave |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2025-02-23T21:00:12+05:30  |  Updated On 23 Feb 2025 9:00 PM IST
Diaphragm Dysfunction Is Common in Asthma and Linked to Disease Severity, finds study
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A new study published in Respiratory Medicine has found that diaphragm dysfunction is more common in asthma patients and is associated with worse disease outcomes, including higher rates of exacerbation and longer disease duration. Asthma, a chronic inflammatory airway condition, has been known to impair lung function and exercise capacity. This study was conducted by Andrea P. and colleagues.

The research enrolled 50 asthma patients and 50 healthy controls in a prospective, observational study of diaphragmatic function. Two separate operators measured diaphragm contraction with tidal breathing thickening fraction (TF), dysfunction being TF < 20%. Other evaluations performed were flow-volume spirometry, impulse oscillometry (IOS), fractional exhaled nitric oxide (FeNO), blood eosinophil count, and Sniff Inspiratory Nasal Pressure (SNIP) testing.

Key Findings

  • Asthmatic patients had greatly reduced diaphragm TF levels than healthy controls (p < 0.0001).

  • 62%–66% of right hemidiaphragm and 46%–54% of left hemidiaphragm cases had diaphragm dysfunction.

  • Decreased diaphragm TF was associated with increased disease duration (p = 0.03) and increased rates of exacerbation (p = 0.04).

  • There were no correlations between diaphragm TF and lung function, Th2 markers, anthropometry, or treatments for asthma.

  • No correlation existed between SNIP test results and diaphragm TF.

  • The cross-sectional design and small sample size of the study were listed as limitations.

The study authors concluded that diaphragm dysfunction is common in asthma and correlates with disease severity, including increased exacerbation frequency and longer disease duration. Identifying and addressing diaphragm impairment may improve symptom management and overall quality of life in asthma patients.

Reference:

Portacci, A., Iorillo, I., Quaranta, V. N., Amendolara, M., Sana, F., Pezzuto, V., Ferrulli, S., Dragonieri, S., & Carpagnano, G. E. (2025). Diaphragm function in patients with asthma and healthy controls: a cross-sectional study. Respiratory Medicine, 108008, 108008. https://doi.org/10.1016/j.rmed.2025.108008

Respiratory MedicineAsthmadiaphragm dysfunctionrespiratory musclesexacerbationsthickening fractionlung functiontreatable traits
Source : Respiratory Medicine
Dr Riya Dave
Dr Riya Dave

    Dr Riya Dave has completed dentistry from Gujarat University in 2022. She is a dentist and accomplished medical and scientific writer known for her commitment to bridging the gap between clinical expertise and accessible healthcare information. She has been actively involved in writing blogs related to health and wellness.

    Dr. Kamal Kant Kohli
    Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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