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Higher adiponectin not tied with increased risk of asthma: Study
![Higher adiponectin not tied with increased risk of asthma: Study Higher adiponectin not tied with increased risk of asthma: Study](https://medicaldialogues.in/h-upload/2022/01/04/750x450_167462-download-16.webp)
Higher adiponectin is not tied with increased risk of asthma according to genetic evidence published in recently in Thorax
Adiponectin, an adipocyte-secreted protein hormone with inflammatory properties, has a potentially important role in the development and progression of asthma. Unravelling whether adiponectin is a causal risk factor for asthma is an important issue to clarify as adiponectin could be a potential novel drug target for the treatment of asthma.
A group of researchers tested the hypothesis that plasma adiponectin is associated observationally and causally (using genetic variants as instrumental variables) with the risk of asthma.
In the Copenhagen General Population Study, we did an observational analysis in 28 845 individuals (2278 asthma cases) with plasma adiponectin measurements, and a genetic one-sample Mendelian randomisation analysis in 94 868 individuals (7128 asthma cases) with 4 genetic variants. Furthermore, in the UK Biobank, we did a genetic two-sample Mendelian randomisation analysis in 462 933 individuals (53 598 asthma cases) with 12 genetic variants. Lastly, we meta-analysed the genetic findings.
The Results of the study are as follows:
While a 1 unit log-transformed higher plasma adiponectin in the Copenhagen General Population Study was associated with an observational OR of 1.65 (95% CI 1.29 to 2.08) for asthma, the corresponding genetic causal OR was 1.03 (95% CI 0.75 to 1.42). The genetic causal OR for asthma in the UK Biobank was 1.00 (95% CI 0.99 to 1.00). Lastly, a genetic meta-analysis confirmed the lack of association between genetically high plasma adiponectin and causal OR for asthma.
Thus, the researchers concluded that observationally, high plasma adiponectin is associated with an increased risk of asthma; however, genetic evidence could not support a causal association between plasma adiponectin and asthma.
Reference:
Plasma adiponectin and risk of asthma: observational analysis, genetic Mendelian randomisation and meta-analysis by Maria Booth Nielsen et al. published in the Thorax.
https://pubmed.ncbi.nlm.nih.gov/34949725/
Dr. Shravani Dali has completed her BDS from Pravara institute of medical sciences, loni. Following which she extensively worked in the healthcare sector for 2+ years. She has been actively involved in writing blogs in field of health and wellness. Currently she is pursuing her Masters of public health-health administration from Tata institute of social sciences. She can be contacted at editorial@medicaldialogues.in.
Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: editorial@medicaldialogues.in. Contact no. 011-43720751