Insomnia Increases Respiratory Infections Risk by More Than 50%

Written By : Dr. Shravani Dali |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2023-06-18T20:00:20+05:30 | Updated On 19 Jun 2023 2:43 PM IST

Insomnia Increases Respiratory Infections Risk by More Than 50% suggests a new study published in the eBioMedicine

Poor sleep is associated with an increased risk of infections and all-cause mortality but the causal direction between poor sleep and respiratory infections has remained unclear. The researchers examined if poor sleep contributes as a causal risk factor to respiratory infections.

Researchers used data on insomnia, influenza and upper respiratory infections (URIs) from primary care and hospital records in the UK Biobank (N ≈ 231,000) and FinnGen (N ≈ 392,000). We computed logistic regression to assess association between poor sleep and infections, disease free survival hazard ratios, and performed Mendelian randomization analyses to assess causality.

Findings

Utilizing 23 years of registry data and follow-up, we discovered that insomnia diagnosis associated with increased risk for infections (FinnGen influenza Cox’s proportional hazard (CPH) HR = 4.34 [3.90, 4.83], P = 4.16 × 10−159, UK Biobank influenza CPH HR = 1.54 [1.37, 1.73], P = 2.49 × 10−13). Mendelian randomization indicated that insomnia causally predisposed to influenza (inverse-variance weighted (IVW) OR = 1.65, P = 5.86 × 10−7), URI (IVW OR = 1.94, P = 8.14 × 10−31), COVID-19 infection (IVW OR = 1.08, P = 0.037) and risk of hospitalization from COVID-19 (IVW OR = 1.47, P = 4.96 × 10−5).

The findings indicate that chronic poor sleep is a causal risk factor for contracting respiratory infections, and in addition contributes to the severity of respiratory infections. These findings highlight the role of sleep in maintaining sufficient immune response against pathogens.

Reference:

Samuel E. Jones i, Fahrisa I. Maisha i, Satu J. Strausz, Vilma Lammi, Brian E. Cade

Anniina Tervi, et al.The public health impact of poor sleep on severe COVID-19, influenza and upper respiratory infections. eBioMedicine. Open AccessPublished:June 08, 2023DOI:https://doi.org/10.1016/j.ebiom.2023.104630

Keywords:

Insomnia, Increases, Respiratory, Infections, Risk, More , Than 50%, eBioMedicine, Samuel E. Jones i, Fahrisa I. Maisha i, Satu J. Strausz, Vilma Lammi, Brian E. Cade, Anniina Tervi, Insomnia, COVID-19, Respiratory infections, Mendelian randomization, Sleep, Severe infection

InsomniaIncreasesRespiratoryInfectionsRiskMoreThan 50%eBioMedicine

Source : eBioMedicine

Dr. Shravani Dali

Dr. Shravani Dali has completed her BDS from Pravara institute of medical sciences, loni. Following which she extensively worked in the healthcare sector for 2+ years. She has been actively involved in writing blogs in field of health and wellness. Currently she is pursuing her Masters of public health-health administration from Tata institute of social sciences. She can be contacted at editorial@medicaldialogues.in.

Dr. Kamal Kant Kohli

Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751