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  • Lungs of deceased...

Lungs of deceased COVID-19 patients show distinctive features

Written By : Hina Zahid |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2020-05-28T07:00:21+05:30  |  Updated On 28 May 2020 11:32 AM IST
Lungs of deceased COVID-19 patients show distinctive features
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Researchers in a new study in the New England Journal of Medicine (NEJM) have outlined morphologic and molecular changes in the peripheral lung of patients who die from Covid-19.

The researchers at Brigham and Women's Hospital, and a team of international researchers examined seven lungs obtained during autopsy from patients who died of COVID-19. They compared this group to seven autopsied lungs obtained from patients who died of acute respiratory distress syndrome secondary to influenza A (H1N1) infection as well as to 10 age-matched uninfected control lungs.

Both COVID-19 and influenza are the same category of virus and both infect the respiratory tract. While the lungs shared some common features, there were distinctive features related to blood vessels seen in the lungs of patients who had died of COVID-19.

Researchers observed that COVID-19 damaged the endothelial cells (vascular lining cells), causing severe endothelial injury. Patients with COVID-19 showed widespread blood clotting as well as new vessel growth -- the latter likely a result of the body's response to the virus. The team saw signs of a distinctive pattern of pulmonary vascular disease progression in some cases of COVID-19 compared to that of equally severe influenza virus infection.

Some of the key points are highlighted below:

COVID-19 is a respiratory virus that causes a vascular disease.

The damage to vascular cells helps explain the serious blot clotting observed in patients.

A unique response, intussusceptive angiogenesis (IA), is the way the body compensates for the thrombosis and blood vessel damage.

Damaged blood vessels may also underlie other problems seen, such as COVID toe, children with Kawasaki, stroke, and other seemingly unrelated problems seen with COVID-19.

The authors concluded that In their small series, vascular angiogenesis distinguished the pulmonary pathobiology of Covid-19 from that of equally severe influenza virus infection.

This study shows the need for more research on angiogenesis and the vascular effects of COVID-19.

For more details click on the link: http://dx.doi.org/10.1056/NEJMoa2015432

covid 19lungblood vesselslung changesCOVID-19
Source : New England Journal of Medicine
Hina Zahid
Hina Zahid

    Hina Zahid Joined Medical Dialogue in 2017 with a passion to work as a Reporter. She coordinates with various national and international journals and association and covers all the stories related to Medical guidelines, Medical Journals, rare medical surgeries as well as all the updates in the medical field. Email: editorial@medicaldialogues.in. Contact no. 011-43720751

    Dr. Kamal Kant Kohli
    Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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