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  • Maternal asthma...

Maternal asthma medication associated with premature births, small birth weight in infants

Written By : Hina Zahid |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2020-12-28T16:00:00+05:30  |  Updated On 28 Dec 2020 4:00 PM IST
Maternal asthma medication associated with premature births, small birth weight in infants
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Prescriptions for asthma medicines, whether continued or discontinued during pregnancy, are associated with premature births and small birth weight, according to a new study published this week in the open-access journal PLOS ONE by Sue Jordan of Swansea University and colleagues.

The prevalence of asthma in pregnancy has increased worldwide in recent years and these is no consensus on the effect of asthma or asthma medications on perinatal outcomes. However, it is known that medicines prescribed for asthma can cross the placenta.

In the new study, researchers analyzed all births in Wales after 24 gestational weeks between January 2000 and December 2010, with associated maternal prescription data (117,717 births). Exposure to any asthma medication was defined as the woman having been prescribed at least one asthma medicine in the three trimesters of pregnancy. Pregnancies terminated for fetal anomalies, infants with congenital anomalies, pregnancies that were not singletons, and those exposed to other drugs or substances associated with perinatal outcomes were excluded.

Prescriptions for asthma were associated with birth before 32 weeks gestation (aOR 1.33, 95%CI 1.10-1.61) and birthweights below the 10th percentile (aOR 1.10, 95%CI 1.03-1.18). Moreover, the discontinuation of asthma medicine during pregnancy was associated with both birth before 32 weeks (aOR 1.53, 95%CI 1.11-2.10) and birth before 37 weeks gestation (aOR 1.22, 95%CI 1.06-1.41). Stillbirth was also more prevalent among women prescribed asthma medicines than the unexposed population (aOR 1.56, 95%CI 1.21-2.00), particularly if the medicines had been discontinued during pregnancy (aOR 1.91, 95%CI 1.29-2.82). The authors conclude that increased monitoring, targeted support and active asthma management are needed before, during and after pregnancy.

The authors add: "This analysis of prescription records for over 100,000 pregnancies found that women who stopped their asthma medicines during pregnancy were at increased risk of preterm birth and not breastfeeding at 6-8 weeks, whereas women who continued with their inhaled corticosteroids were at lower risk. Prescriptions records could be used to identify the women who need extra help and support.

plos oneasthmapremature birthssmall birthpregnancyplacentabirthweights
Source : PLOS ONE
Hina Zahid
Hina Zahid

    Hina Zahid Joined Medical Dialogue in 2017 with a passion to work as a Reporter. She coordinates with various national and international journals and association and covers all the stories related to Medical guidelines, Medical Journals, rare medical surgeries as well as all the updates in the medical field. Email: editorial@medicaldialogues.in. Contact no. 011-43720751

    Dr. Kamal Kant Kohli
    Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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