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  • Prenatal ultrafine...

Prenatal ultrafine particle exposure linked to asthma development in children, Study reports

Written By : Dr. Nandita Mohan |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2021-08-10T09:00:37+05:30  |  Updated On 10 Aug 2021 5:50 PM IST
Prenatal ultrafine particle exposure linked to asthma development in children, Study reports
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Ambient ultrafine particles (UFPs; <0.1 µm) may exert greater toxicity, compared to other pollution components, due to enhanced oxidative capacity and ability to translocate systemically. Studies examining associations between prenatal UFP exposure and childhood asthma remain sparse.

A recent research published in the has highlighted that prenatal ultrafine particles (UFP) exposure is associated with asthma development in children, independent of correlated ambient NO2 and temperature.

Rosalind J. Wright and colleagues from the Icahn School of Medicine, Environmental Medicine & Public Health, New York, United States daily used ultrafine particle exposure estimates to identify susceptible windows of prenatal ultrafine particle exposure with asthma in children, accounting for sex-specific effects.

Analyses included a total of 376 mother-child dyads followed since pregnancy. Daily ultrafine particle exposure during pregnancy was estimated using a spatiotemporally-resolved particle number concentration prediction model.

Bayesian distributed lag interaction models (BDLIMs) were used to identify sensitive windows for UFP exposure, and examine whether effect estimates varied by sex. Incident asthma was determined at first report of asthma (3.6+3.2 years).

Covariates included maternal age, education, race, and obesity, child sex, nitrogen dioxide (NO2) and temperature averaged over gestation, and postnatal ultrafine particle exposure.

The following findings were observed-

a. Women were 37.8% Black and 43.9% Hispanic with 52.9% reporting

b. The cumulative odds ratio (95% confidence interval) for incident asthma, per doubling of ultrafine particle exposure level across pregnancy was 4.28 (1.41–15.7) impacting males and females similarly. c. Bayesian distributed lag interaction models indicated sex differences in the sensitive windows with the highest risk of asthma in females exposed to higher UFPs during late pregnancy.

Hence, it was concluded that prenatal ultrafine particle exposure was associated with asthma development in children, independent of correlated ambient NO2 and temperature. Findings will benefit future research and policy-makers considering appropriate regulations that reduce the adverse effects of ultrafine particle on child respiratory health.

https://doi.org/10.1164/rccm.202010-3743OC


Prenatal ultrafine particleasthmachildrenAmerican Journal of Respiratory and Critical Care Medicine
Source : American Journal of Respiratory and Critical Care Medicine
Dr. Nandita Mohan
Dr. Nandita Mohan

    Dr. Nandita Mohan is a practicing pediatric dentist with more than 5 years of clinical work experience. Along with this, she is equally interested in keeping herself up to date about the latest developments in the field of medicine and dentistry which is the driving force for her to be in association with Medical Dialogues. She also has her name attached with many publications; both national and international. She has pursued her BDS from Rajiv Gandhi University of Health Sciences, Bangalore and later went to enter her dream specialty (MDS) in the Department of Pedodontics and Preventive Dentistry from Pt. B.D. Sharma University of Health Sciences. Through all the years of experience, her core interest in learning something new has never stopped. She can be contacted at editorial@medicaldialogues.in. Contact no. 011-43720751

    Dr. Kamal Kant Kohli
    Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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