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  • Scientists propose...

Scientists propose low-dose rapamycin for protecting elderly from COVID-19,

Written By : Hina Zahid |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2020-04-07T18:45:04+05:30  |  Updated On 7 April 2020 6:45 PM IST
Scientists propose low-dose rapamycin for protecting elderly from COVID-19,
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London, UK -Alex Zhavoronkov, PhD, the chief scientist of the Biogerontology Research Foundation has proposed repurposing of known geroprotectors such as rapamycin, nicotinamide riboside, nicotinamide mononucleotide, metformin, and other drugs with the known safety profile for prevention of Covid 19 infection in elderly.

The Biogerontology Research Foundation, a registered UK charity supporting and promoting aging and longevity research worldwide since 2008, today announced the publication of a paper titled "Geroprotective and senoremediative strategies to reduce the comorbidity, infection rates, severity, and lethality in gerophilic and gerolavic infections" in the leading journal Aging.

Vaccines and therapeutic solutions for COVID-19 are still far from the clinic and will not provide complete protection, and likely to be less effective in the elderly. Recent BBC article notes "It will, almost inevitably, be less successful in older people. This is not because of the vaccine itself, but aged immune systems do not respond as well to immunisation. We see this every year with the flu jab."

The author of the study, Alex Zhavoronkov, PhD, the chief scientist of the Biogerontology Research Foundation and the CEO of an artificial intelligence company Insilico Medicine proposed calling SARS-CoV-2 and other infections that are more infectious and harmful to the elderly as gerophilic and gerolavic infections.

He also proposed a strategy for repurposing known geroprotectors such as rapamycin, nicotinamide riboside, nicotinamide mononucleotide, metformin, and other drugs with the known safety profile for prevention of SARS-CoV-2 infection. The scientist analyzed the prior clinical studies of everolimus (RAD001) in healthy elderly, and previous evidence showing paradoxical immunopotentiation effects of rapamycin and proposed additional clinical trials for these molecules in the healthy elderly population.

Zhavoronkov also proposed the use of inexpensive and minimally-invasive deep aging clocks to track the efficacy of these preventative geroprotective interventions and to stratify the patients by predicted severity of COVID-19.

"We are pursuing several strategies for drug discovery and repurposing using the latest advances in artificial intelligence integrated into our battle-tested discovery platform. However, it is clear that COVID-19 is a gerophilic and gerolavic disease. It is more severe and lethal in the elderly. Aging research yields insights that may not only help with COVID-19 but may help prevent many other diseases and increase productive longevity and re-ignite the economy", said Alex Zhavoronkov, PhD.

Previous studies by the BGRF scientists including "Biomedical Progress Rates as New Parameters for Models of Economic Growth in Developed Countries", and books including "The Ageless Generation: How Advances in Biomedicine Will Transform the Global Economy" show that extending productive longevity in the developed countries will lead to unprecedented economic growth.

"Most of the companies and institutions are racing to create vaccines or drugs that target COVID directly. But these interventions will not offer complete protection. We see that children and very young people do not have severe symptoms. Geroprotectors may help improve the odds for the elderly. And once the epidemic subsides, we will need to find new ways to boost the economy and there are established models showing that the best way to grow the economy is by increasing healthy productive longevity", said Dmitry Kaminskiy, managing trustee of the Biogerontology Research Foundation.

"This is the first review highlighting geroprotective strategies that may decrease the disease burden of gerolavic infections such as COVID-19. It presents a case for further research and clinical studies to validate markers of biological age in the context of viral infections. Ageing Research at King's (ARK) is partnering with BGRF and Insilico Medicine to identify mechanisms by which geroprotectors enhance resilience against infections and reduce the severity of symptoms. The proposed research will acutely help physicians treat COVID-19, protect the elderly and benefit long term global health and longevity." said Dr. Richard Siow, Director of ARK and former Vice-Dean (International), Faculty of Life Sciences & Medicine, King's College London.

For more details click on the link: http://dx.doi.org/10.18632/aging.102988

covid-19rapamycingerolavic infectionsAgingartificial intelligencecoronavirus
Source : Aging
Hina Zahid
Hina Zahid

    Hina Zahid Joined Medical Dialogue in 2017 with a passion to work as a Reporter. She coordinates with various national and international journals and association and covers all the stories related to Medical guidelines, Medical Journals, rare medical surgeries as well as all the updates in the medical field. Email: editorial@medicaldialogues.in. Contact no. 011-43720751

    Dr. Kamal Kant Kohli
    Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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