Swedish Study significantly links bronchial Asthma with Diabetes
A significant association was found between asthma and type 2 diabetes (T2D), even after adjusting for body mass index (BMI). Additionally, individuals with a sibling affected by one condition had an increased likelihood of having the other condition, indicating shared genetic and environmental factors.
Asthma and type 2 diabetes are two important causes of morbidity globally. They examined both the association of type 2 diabetes with asthma in Swedish adults and the familial co-aggregation of the diseases. They conducted a cross-sectional study of all adults aged 25–85 in Sweden between 2009 and 2013. Asthma and type 2 diabetes status were ascertained from the health registers. Models were adjusted for sex, age, education level, income and country of birth and in a subset, for body mass index (BMI). They further conducted a familial coaggregation analysis to determine if shared familial factors could explain any observed findings. Results The study included 5,299,245 participants, 25,292 (0.5%) had both asthma and type 2 diabetes. In the total population, the OR for the association between type 2 diabetes and asthma was 1.47 (95% CI 1.45 to 1.49); in the population of men (1.30 (95% CI 1.27 to 1.32)) and women (1.63 (95% CI 1.60 to 1.66)). The ORs were slightly higher among men (1.51 (95% CI 1.45 to 1.56)) and women (2.04 (95% CI 1.96 to 2.11)) for whom BMI measurements were available but attenuated with adjustment for BMI (1.45 (95% CI 1.40 to 1.51)) and (1.76 (95% CI 1.68 to 1.84)). Diabetes was more likely if a full sibling had asthma than if the sibling did not (1.13 (95% CI 1.10 to 1.15)). They found an association between asthma and type 2 diabetes that was sustained after adjusting for BMI, indicating that BMI alone does not explain this relationship. They also found that the two conditions coaggregate in siblings, indicating that the association is partly due to shared familial genetic and environmental risk factors.
Mubanga M, Gong T, Smew AI, et al. Association between asthma and type 2 diabetes in a Swedish adult population: a register-based cross-sectional study. Thorax Published Online First: 23 March 2025. doi: 10.1136/thorax-2024-222819
Keywords:
Mubanga M, Gong T, Smew AI, Thorax, Association, asthma, type, 2 diabetes, Swedish, adult, population, register-based, cross-sectional, study
