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  • Elastography useful...

Elastography useful for breast cancer screening in microcalcification cases: Study

Medha BaranwalWritten by Medha Baranwal Published On 2021-06-25T09:15:00+05:30  |  Updated On 25 Jun 2021 3:45 AM GMT
Elastography useful for breast cancer screening in microcalcification cases: Study
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Istanbul, Turkey: Shear-wave elastography (SWE) is a useful method for characterizing suspicious microcalcifications (MCs) in women undergoing breast cancer screening, finds a recent study. This would help in making a decision on whether the patient should receive a second biopsy or excision. The findings of the study are published in the journal Ultrasound in Medicine and...

Istanbul, Turkey: Shear-wave elastography (SWE) is a useful method for characterizing suspicious microcalcifications (MCs) in women undergoing breast cancer screening, finds a recent study. This would help in making a decision on whether the patient should receive a second biopsy or excision. 

The findings of the study are published in the journal Ultrasound in Medicine and Biology.

"Despite biopsy being recommended for showing suspicious microcalcifications, 2D shear-wave elastography is a "useful" method for characterizing microcalcifications that can be visualized with ultrasonography (USG)," wrote the authors. 

Yasemin Kayadibi, Istanbul Universitesi-Cerrahpasa, Kocamustafapasa, Istanbul, Turkey, and colleagues aimed to investigate the correlations between the findings of two-dimensional shear-wave elastography and the histopathologic results of microcalcifications visualized using ultrasonography.

For this purpose, the researchers evaluated five people with suspicious MCs without accompanying mass. They underwent USG and 2D-SWE before USG-guided tru-cut biopsy. They then compared SWE values and histopathologic features statistically. Using the Mann–Whitney U test, the variables between groups were analyzed. Receiver operating characteristic analysis was performed and cut-off values determined to discriminate malignancy, invasiveness and high grade. 

Key findings of the study include:

  • Pathology confirmed 27 malignant lesions (18 invasive ductal carcinomas, one invasive lobular and eight ductal carcinomas in situ) and 23 benign ones.
  • There was a statistically significant difference between the SWE values of malignant and benign MCs.
  • The diagnostic performance of SWE for malignancy, invasiveness and high grade were as follows, repectively: sensitivity (93%, 83%, 88%), specificity (91%, 88%, 53%), positive predictive value (93%, 94%, 44%), negative predictive value (91%, 70%, 90%) and area under the curve (0.952, 0.885, 0.776).
  • Cut-off values were determined as 57 kPa for malignancy, 124 kPa for invasiveness and 124.5 kPa for high grade.

"Our findings show that SWE is a useful method in clinical practice for characterizing MCs that can be visualized with USG," concluded the authors. 

Reference:

The study titled, "Characterization of Suspicious Microcalcifications on Mammography Using 2D Shear-Wave Elastography," is published in the journal Ultrasound in Medicine and Biology.

DOI: https://www.umbjournal.org/article/S0301-5629(21)00219-2/fulltext


Ultrasound in Medicine and Biologyshear wave elastographybreast cancermicrocalcifications
Source : Ultrasound in Medicine and Biology
Medha Baranwal
Medha Baranwal

    MSc. Biotechnology

    Medha Baranwal joined Medical Dialogues as an Editor in 2018 for Speciality Medical Dialogues. She covers several medical specialties including Cardiac Sciences, Dentistry, Diabetes and Endo, Diagnostics, ENT, Gastroenterology, Neurosciences, and Radiology. She has completed her Bachelors in Biomedical Sciences from DU and then pursued Masters in Biotechnology from Amity University. She has a working experience of 5 years in the field of medical research writing, scientific writing, content writing, and content management. She can be contacted at  editorial@medicaldialogues.in. Contact no. 011-43720751

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