Hepatic steatosis detection by ultrasound versus MRI proton-density fat fraction

Leesburg, VA: According to ARRS' American Journal of Roentgenology (AJR), ultrasound-derived fat fraction (UDFF) is strongly associated with MRI proton-density fat fraction (PDFF) and provides high sensitivity for detecting hepatic steatosis.

Noting that a reduced number of measurements is sufficient for determining overall UDFF (i.e., median value of the median of the five measurements for each of three acquisitions), "a UDFF cutoff of >5% provides high AUC and sensitivity, albeit low specificity, for detection of MRI PDFF ≥5.5%," clarified corresponding author Andrew T. Trout of Cincinnati Children's Hospital Medical Center in Ohio.

Trout and team's cross-sectional study registered 56 overweight and obese adolescents and adults (≥16 years) who underwent investigational ultrasound (ACUSON Sequoia; deep abdominal transducer) and MRI examinations of the liver during a single visit from August to October 2020. Ultrasound examinations included three UDFF acquisitions of five measurements each. MRI examinations included three PDFF acquisitions with calculation of an overall median PDFF.

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https://arrs.org/ARRSLIVE/Pressroom/PressReleases/Hepatic_Steatosis_Ultrasound_MRI.aspx