Reduced-dose CT effectively detects lung nodule in kids and young adults with cancer: Study
USA: Reduced-dose CT may be a feasible option for detection of pulmonary metastatic disease in situations in which radiation dose is a primary consideration or as an option to reduce dose in patients undergoing serial chest CT to monitor known disease, suggests a recent study.
This is because reduced-dose CT can depict greater than 90% of lung nodules in children and young adults with cancer. The presence of nodules were identified with moderate sensitivity and high specificity.
"CT performed at 0.3 mSv mean effective dose has acceptable diagnostic performance for lung nodule detection in children and young adults and has the potential to reduce patient dose or expand CT utilization (e.g., to replace radiography in screening or monitoring protocols), the authors wrote in American Journal of Roentgenology (AJR).
Trout and colleagues' prospective study enrolled patients 4-21 years old with known or suspected malignancy who were undergoing clinically indicated chest CT. Study participants underwent an additional investigational reduced-dose chest CT in the same imaging encounter. Three independent radiologists blind-reviewed the separated and deidentified CT examinations, with one radiologist performing a subsequent review to match nodules between the standard- and reduced-dose examinations.
Among the 78 patients (44 male, 34 female; mean age, 15.2 years) with cancer who underwent standard-dose chest CT and reduced-dose chest CT (mean effective dose 0.3 ± 0.1 mSv, representing 83% dose reduction) in the same imaging encounter, the reduced-dose protocol detected greater than 90% of lung nodules identified on the standard-dose examination.
Noting that no prior study has directly compared clinical to reduced-dose CT for detection of lung nodules in children, "reduced-dose CT may be a feasible option for detection of pulmonary metastatic disease in situations in which radiation dose is a primary consideration or as an option to reduce dose in patients undergoing serial chest CT to monitor known disease," the authors of this AJR article concluded.
Reference:
The study titled, "Comparison of 0.3-mSv CT to Standard-Dose CT for Detection of Lung Nodules in Children and Young Adults With Cancer," is published in the American Journal of Roentgenology.
https://www.ajronline.org/doi/10.2214/AJR.21.26183
