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  • Refined CT imaging can...

Refined CT imaging can identify residual thrombi 1 year after acute Pulmonary embolism

Medha BaranwalWritten by Medha Baranwal Published On 2022-04-27T12:30:45+05:30  |  Updated On 27 April 2022 10:28 AM GMT
Refined CT imaging can identify residual thrombi 1 year after acute Pulmonary embolism
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Japan: A team of researchers from Japan reported a high prevalence (74%) of residual thrombi 1 year after acute pulmonary embolism (PE) using refined computed tomography (CT) imaging. Precise CT imaging can therefore be included in the long-term treatment strategy of acute PE. The findings of the study appear in the Journal of Thrombosis and Haemostasis. Post-pulmonary embolism syndrome is...

Japan: A team of researchers from Japan reported a high prevalence (74%) of residual thrombi 1 year after acute pulmonary embolism (PE) using refined computed tomography (CT) imaging. Precise CT imaging can therefore be included in the long-term treatment strategy of acute PE. The findings of the study appear in the Journal of Thrombosis and Haemostasis. 

Post-pulmonary embolism syndrome is an important clinical condition that can impact the long-term prognosis after acute PE. Yoshihisa Nakano and colleagues aimed to evaluate the prevalence of residual pulmonary thrombi and the thrombotic burden 1 year after acute PE, by using a refined CT imaging method in a prospective study. 

The researchers recruited patients diagnosed with acute PE and examinations were conducted at 1 month, 6 months, and 1 year. Especially at 1 year, patients were evaluated multifacetedly, including laboratory tests, 6-min walking test, quality-of-life, and enhanced CT. 

The findings of the study were as follows:

  • Fifty-two patients were enrolled. Two patients (3.8%) developed chronic thromboembolic pulmonary hypertension.
  • A total of 43 patients completed evaluation at 1 year, among whom (74%) had residual thrombi, with a median modified CT obstruction index (mCTOI) of 10.7%.
  • In multivariate analysis, residual thrombi at 1 month was the only factor significantly related to residual thrombi at 1 year (odds ratio, 103.4).
  • The tricuspid regurgitation pressure gradient ≥60 mmHg and left ventricular end-diastolic dimension at diagnosis were significantly related to mCTOI at 1 year (β = 0.367 and β = –0.435 respectively).

"We found a high incidence of residual pulmonary thrombi 1 year after acute PE using enhanced CT imaging protocol. Furthermore, right ventricular overload was significantly related to the thrombotic burden," the researchers wrote in their study.

They suggest, that "the treatment strategy for acute PE should include the modified CT imaging protocol with mCTOI for accurately monitoring residual pulmonary thrombotic burden."

Reference:

The study titled, "Usefulness of a refined computed tomography imaging method to assess the prevalence of residual pulmonary thrombi in patients 1 year after acute pulmonary embolism: The Nagoya PE study," was published in the Journal of Thrombosis and Haemostasis.

DOI: https://doi.org/10.1111/jth.15636

Journal of Thrombosis and Haemostasisacute pulmonary embolismcomputed tomography
Source : Journal of Thrombosis and Haemostasis
Medha Baranwal
Medha Baranwal

    MSc. Biotechnology

    Medha Baranwal joined Medical Dialogues as an Editor in 2018 for Speciality Medical Dialogues. She covers several medical specialties including Cardiac Sciences, Dentistry, Diabetes and Endo, Diagnostics, ENT, Gastroenterology, Neurosciences, and Radiology. She has completed her Bachelors in Biomedical Sciences from DU and then pursued Masters in Biotechnology from Amity University. She has a working experience of 5 years in the field of medical research writing, scientific writing, content writing, and content management. She can be contacted at  editorial@medicaldialogues.in. Contact no. 011-43720751

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