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  • Single-Phase CT with...

Single-Phase CT with Clinical Data Matches Dual-Phase CT for COPD Staging: Study

Written By : Dr Riya Dave |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2025-01-06T20:45:21+05:30  |  Updated On 7 Jan 2025 12:29 PM IST
Single-Phase CT with Clinical Data Matches Dual-Phase CT for COPD Staging: Study
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Researchers have discovered that single-phase CT scans along with clinical data can achieve accuracy equivalent to dual-phase inspiratory-expiratory CT imaging in chronic obstructive pulmonary disease (COPD) staging. A recent study was conducted by Amanda N. and colleagues which was published in the journal of Radiology: Cardiothoracic Imaging.

COPD staging is essential for disease management. Traditionally, this was based on spirometry measurement, including forced expiratory volume in 1 second (FEV1) percent predicted, and the ratio of FEV1/FVC. Recent advances in convolutional neural networks (CNNs) have enabled integrating imaging and clinical data for prediction of spirometry values and classification of COPD stages according to the Global Initiative for Chronic Obstructive Lung Disease (GOLD) criteria. This research was designed to determine if the accuracy of dual-phase CT can be equalled or even surpassed with single-phase CT scans together with clinical data for COPD staging by CNN-based methods.

Retrospective analysis was used, where the participants came from COPDGene phase I. There were 8893 participants who had a mean age of 59.6 years ± 9.0. Among these participants, 53.3% were male (4738). Clinical data and CT images were used to train CNNs in order to predict spirometry values and GOLD stage. Comparison between single-phase inspiratory or expiratory CT scans versus dual-phase CT (inspiratory-expiratory)

Predictions from intraclass correlation coefficient (ICC) on the assessment of spirometry, and accuracy measures for the classification into the GOLD stage

Key findings

Agreement Between CNN Predictions and Reference Spirometry:-

• CNN-predicted spirometry values were of moderate to good agreement compared to the reference spirometry values, with an ICC ranging between 0.66–0.79.

• The inclusion of clinical data increased the agreement (ICC, 0.70–0.85; p ≤0.04), except for FEV1/FVC in the inspiratory-phase CNN model (p=0.35) and FEV1 in the expiratory-phase CNN model (p =0.33).

Accuracy by GOLD Stage

• Single-phase CT CNNs had moderate to good agreement (ICC, 0.68–0.70) with accuracies of 59.8% to 84.1% (682–959 of 1140).

• Dual-phase CT CNNs had higher accuracies of 60.0% to 86.3% (684–984 of 1140) with an ICC of 0.72.

Impact of Clinical Data:

Inclusion of clinical data markedly improved both single-phase and dual-phase CNN models:

• The single-phase CNN achieved an accuracy of 65.2%–85.8% (743–978 of 1140) with an ICC of 0.72.

• The dual-phase CNN achieved an accuracy of 67.6%–88.0% (771–1003 of 1140) with an ICC of 0.77–0.78.

• But, for the expiratory CNN model, no improvement in GOLD stage ICC was seen (p=0.08).

Single-phase CT combined with clinical data yields accuracy comparable to dual-phase CT for CNN-based COPD staging, thus providing a streamlined and effective approach for disease diagnosis and management. This approach represents a significant step forward in integrating imaging and clinical data for advanced diagnostic applications.

Reference:

Lee, A. N., Hsiao, A., & Hasenstab, K. A. (2024). Evaluating the cumulative benefit of inspiratory CT, expiratory CT, and clinical data for COPD diagnosis and staging through deep learning. Radiology. Cardiothoracic Imaging, 6(6). https://doi.org/10.1148/ryct.240005

Radiology: Cardiothoracic ImagingCOPD stagingCNNsingle-phase CTinspiratory-expiratory CTspirometryGOLD stage
Source : Radiology: Cardiothoracic Imaging
Dr Riya Dave
Dr Riya Dave

    Dr Riya Dave has completed dentistry from Gujarat University in 2022. She is a dentist and accomplished medical and scientific writer known for her commitment to bridging the gap between clinical expertise and accessible healthcare information. She has been actively involved in writing blogs related to health and wellness.

    Dr. Kamal Kant Kohli
    Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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