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  • Plasma therapy trial...

Plasma therapy trial did not show benefit in decreasing Coronavirus mortality risk: AIIMS

Medical Dialogues BureauWritten by Medical Dialogues Bureau Published On 2020-08-16T15:45:15+05:30  |  Updated On 16 Aug 2020 3:45 PM IST
Plasma therapy trial did not show benefit in decreasing Coronavirus mortality risk: AIIMS
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New Delhi - The trial conducted by All India Institute of Medical Sciences (AIIMS) for convalescent plasma therapy on COVID-19 patients did not show much clinical benefit in reducing fatality risk caused due to the virus.

"These are initial analyses. There were two groups of 15 patients each on whom a randomised control trial was done to know the effectiveness of plasma therapy. One group received standard treatment protocol while the other group received convalescent plasma therapy along with standard treatment. It was noted that mortality was similar in both the groups with no much clinical benefits to the patients," Dr Randeep Guleria, Director at AIIMS told ANI.

Read Also: AIIMS Delhi to hold 2nd session of National CGR on COVID-19 issues today

"It is also important to note that we need more evidence on it to conclude anything. Current evidence suggests that convalescent plasma is safe, does not cause any harm to a patient. But at the same time, it (plasma therapy) is not very effective and hence should be used prudently," Dr Guleria further said.

It may be noted that the Union Health Ministry in its clinical management protocol for COVID19 patients has described the use of convalescent plasma therapy as one of the investigational therapies.

The treatment protocol states that convalescent plasma therapy may be considered in patients with the moderate disease who are not improving (oxygen requirement is progressively increasing) despite the use of steroids.

The dose for convalescent plasma can be variable ranging from 4 to 13 ml/kg (usually 200 ml single dose given slowly over not less than 2 hours).

"There are special prerequisites while considering convalescent plasma. It includes ABO compatibility and cross-matching of the donor plasma. Recipients should be closely monitored for several hours post-transfusion for any transfusion related adverse events. However, the use of convalescent plasma should be avoided in patients with IgA deficiency or immunoglobulin allergy," read clinical guidelines.

Meanwhile, the Indian Council of Medical Research (ICMR) is also conducting trials to evaluate the efficacy of plasma therapy, however, results have not been published yet.

Read Also: AIIMS, PGI Chandigarh among 17 trial sites for conducting human trials of COVID vaccine by Oxford

aiimsaiims new delhiall india institute of medical sciencesPlasma therapyCovid 19Dr Randeep Guleria
Source : ANI
Medical Dialogues Bureau
Medical Dialogues Bureau

    Medical Dialogues Bureau consists of a team of passionate medical/scientific writers, led by doctors and healthcare researchers.  Our team efforts to bring you updated and timely news about the important happenings of the medical and healthcare sector. Our editorial team can be reached at editorial@medicaldialogues.in.

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