Novel Absorbable Micro-Aesthetic Lifting Thread Demonstrates Effective and Safe Correction of Nasolabial Folds: Study
Researchers have found in a clinical study that a treatment regimen combining a novel absorbable micro-aesthetic lifting thread with a multi-plane lifting strategy was effective and safe for the correction of nasolabial folds (NLFs). The approach demonstrated non-inferiority to an established marketed comparator while showing potential advantages in investigator-rated satisfaction and early aesthetic improvement.In addition to achieving comparable efficacy and safety, the novel lifting thread exhibited superior handling characteristics, suggesting that it may offer practical and aesthetic benefits for facial rejuvenation procedures involving nasolabial fold correction.
Absorbable lifting threads achieve lifting and support of facial soft tissues through subcutaneous implantation, eventually degrading naturally within the body. They are applied for the correction of nasolabial fold (NLF). This study evaluated the efficacy and safety of a novel absorbable micro-aesthetic lifting thread compared with a marketed polydioxanone thread for correcting moderate-to-severe NLF. A prospective, multicenter, randomized, evaluator-blinded, parallel-controlled design was utilized. A total of 151 subjects with a NLF severity of grade ≥ 3 on the Wrinkle Severity Rating Scale (WSRS) were enrolled and randomized to the experimental group or control group. The primary endpoint was the 7-month WSRS response rate (≥ 1 grade improvement). Secondary endpoints included short-term response rates, Global Aesthetic Improvement Scale (GAIS) scores, device handling performance, and safety indicators.
The 7-month response rate in the full analysis set was 71.6% for the experimental group and 62.7% for the control group. The difference was 8.95% (95% CI − 6.06–23.97%), confirming non-inferiority. The experimental group was significantly superior to the control group in the response rate at 3 months post-procedure, as well as in investigator satisfaction and barb fixation performance (P < 0.05). Both groups exhibited comparable safety profiles with no serious adverse events.
The clinical regimen combining the novel absorbable micro-aesthetic lifting thread with a multi-plane lifting strategy is effective and safe for NLF correction, demonstrating non-inferiority to the marketed comparator. It exhibits potential advantages in terms of investigator satisfaction and early aesthetic improvement, along with superior handling performance.
Reference:
Jia, D., Song, K., Ting, W. et al. Absorbable Micro-Aesthetic Lifting Thread for Nasolabial Fold Correction: A Multicenter, Randomized, Evaluator-Blinded, Parallel-Controlled Clinical Trial. Aesth Plast Surg (2026). https://doi.org/10.1007/s00266-026-06099-1
