Topical moxifloxacin Shows Promise in Enhancing Post-Laparoscopy Wound Healing: Study
Researchers have found in a new Clinical trial that topical moxifloxacin may accelerate healing of therapeutic laparoscopy-induced wounds by reducing redness, edema, bruising, and discharge, while maintaining a favorable safety profile.
Wound healing is crucial for maintaining healthy skin and preventing complications. Topical administration is a preferred method for delivering therapeutic medicines at the surgery site, as it is simple, affordable, and does not result in systemic harm or antibiotic resistance. Moxifloxacin (MXF), a broad-spectrum antibiotic with anti-inflammatory effects, seems to be effective against bacteria and accelerates wound healing. This study aims to determine the therapeutic effect of topical MXF on wound healing after therapeutic laparoscopy. This double-blind clinical trial involved 80 patients with therapeutic laparoscopy-induced wounds, randomly assigned to either 0.5% MXF cream or placebo, 24 h after surgery. The primary outcome was wound healing assessment using the REEDA index. Patients were followed by 1, 3, and 5 days of inclusion.Results: Of the 80 study participants included, 50 were women (62.5%), with the mean (SD) age of the participants being 49.5 (19.8) years in the MXF group and 45.8 (17.8) years in the control group. The severity of redness, oedema, and discharge in the MXF group was significantly lower on the first, third, and fifth days of treatment. The case group showed a significant decrease in ecchymosis from the third day of treatment compared to the control group, and no significant difference was observed in wound approximation rate. Hence, topical MXF therapy yielded a significant decrease in REEDA index MXF (P-Value < 0.0001). No treatment-related serious adverse events occurred in the MXF group vs. the comparator group. The results of the current clinical trial demonstrated that the use of topical MXF could be a potential option to expedite therapeutic laparoscopy-induced wound healing by
Reference:
Heydari, B., Basiratian, A., Hoseinzade, F. et al. Efficacy of topical moxifloxacin on therapeutic laparoscopy-induced wound healing: a double-blind, randomized clinical trial. BMC Surg 25, 198 (2025). https://doi.org/10.1186/s12893-025-02932-7
Keywords:
Topical, moxifloxacin, Shows, Promise, Enhancing, Post-Laparoscopy, Wound, Healing, Study, Heydari, B., Basiratian, A., Hoseinzade, F
