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A reversible male contraceptive, targeted to the testes with magnets
Researchers have developed magnetic, biodegradable nanomaterials that act as long lasting reversible in animal studies.
Women have several choices for long-lasting, reversible contraceptives, but most options for men are either single-use, such as condoms, or difficult to reverse, like vasectomies. Now, in a step toward a safe, long-lasting and reversible male contraceptive,
The research has been reported in ACS' Nano Letters.
Elevated temperatures, which can be caused by wearing too-tight pants or underwear, can decrease sperm count in men. Some researchers have explored the more intense heating of nanomaterials injected into the testes as a form of male birth control. However, the injection can be painful, the heating can damage skin, and most nanomaterials tested so far are not biodegradable. Weihua Ding, Fei Sun and colleagues wanted to develop a safe, effective magnetic-thermal approach to male contraception that doesn't need to be injected directly into the testes.
The researchers tested two forms of iron oxide nanoparticles, which are biodegradable and can be guided and heated with magnetic fields, as male contraceptives. One type of nanoparticle was coated with polyethylene glycol (PEG) and the other with citric acid. Although the PEG-coated nanoparticles could be heated to higher temperatures, they were not as easily manipulated by magnets as the other ones. So the researchers injected repeated doses of citric acid-coated nanoparticles into the bloodstream of mice for 2 days, guided the nanomaterials to the testes with magnets, and then applied an alternating magnetic field to the area for 15 minutes. The nanoparticles heated the testes to a temperature of 104 F, shrinking them and inhibiting spermatogenesis before gradual recovery 30 to 60 days after treatment. The mice couldn't father any pups 7 days after treatment, but they were back to fathering about 12 pups per pregnant female at day 60. The nanoparticles were non-toxic to cells and were gradually eliminated from the body, offering new possibilities for male contraception, the researchers say.
https://pubs.acs.org/doi/abs/10.1021/acs.nanolett.1c02181
Hina Zahid Joined Medical Dialogue in 2017 with a passion to work as a Reporter. She coordinates with various national and international journals and association and covers all the stories related to Medical guidelines, Medical Journals, rare medical surgeries as well as all the updates in the medical field. Email:Â editorial@medicaldialogues.in. Contact no. 011-43720751
Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751