C-reactive protein to albumin ratio, an indicator of erectile dysfunction: Study

Written By : Medha Baranwal |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2021-05-22T09:00:00+05:30 | Updated On 22 May 2021 9:00 AM IST

Turkey: Increased serum C‐reactive protein (CRP) to albumin ratio (CAR) is associated with increased erectile dysfunction (ED) risk and its severity, according to a recent study in the journal Andrologia.

"The results indicate that CAR levels may be useful in assessing ED risk as an inflammatory marker and play an important role in ED etiology," wrote the authors.

Selamettin Demir and İrfan Şafak Barlas from Van Training and Research Hospital, Edremit, Turkey aimed to evaluate whether an independent indicator of erectile dysfunction is C‐reactive protein/albumin ratio.

For this purpose, the researchers prospectively evaluated CAR, demographic features and other criteria of 198 patients with ED who visited the researchers' outpatient clinic during March 2019–April 2020. The study also included healthy control subjects without systemic or infectious diseases.

Key findings of the study include:

The mean difference of CAR between ED and no ED was statistically significant (0.55 ± 0.27 and 0.79 ± 0.49).
On the basis of the ROC analysis, CAR has a good ED diagnostic value with an area under the curve (AUC) of 0.63 and better diagnostic performance to distinguish ED severity (AUC:0.73).
Mean CAR gradually increased with increasing severity of ED.
The CAR has been described as an independent ED indicator in the multivariate analysis.

"The study showed substantially higher CAR and CRP serum levels in ED patients compared with that of control. We observed the vali-date CAR versus CRP cut- off value for predicting ED. These results indicate that CAR levels can be of interest in assessing ED risk as an inflammatory marker and play a key role in ED aetiology," wrote the authors. "In order to explain the relationship between CAR, CRP and ED rates, future researches with larger sample sizes are required."

Reference:

The study titled, "An independent indicator of erectile dysfunction is C‐reactive protein/albumin ratio," is published in the journal Andrologia.

DOI: https://onlinelibrary.wiley.com/doi/10.1111/and.14073

journal Andrologiaerectile dysfunctionC reactive proteinalbumin

Source : Andrologia

Medha Baranwal

MSc. Biotechnology

Medha Baranwal joined Medical Dialogues as an Editor in 2018 for Speciality Medical Dialogues. She covers several medical specialties including Cardiac Sciences, Dentistry, Diabetes and Endo, Diagnostics, ENT, Gastroenterology, Neurosciences, and Radiology. She has completed her Bachelors in Biomedical Sciences from DU and then pursued Masters in Biotechnology from Amity University. She has a working experience of 5 years in the field of medical research writing, scientific writing, content writing, and content management. She can be contacted at editorial@medicaldialogues.in. Contact no. 011-43720751

Dr. Kamal Kant Kohli

Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751