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Chronic marijuana use may decrease testicular function, negatively impact male reproductive health
Chronic use of marijuana may greatly impact male fertility and reproductive outcomes, says a new report published online in the journal Fertility & Sterility. The study is the first to assess the impacts of substance use on testicular function via a mode of delivery, and dosage, that reflects current human consumption.
Clinician-scientists at the Oregon National Primate Research Center at Oregon Health & Science University monitored the reproductive systems of healthy male nonhuman primates following exposure to Delta-9-tetrahydrocannabinol, or THC - the main psychoactive ingredient in marijuana.
The nonhuman primates, all of reproductive age with a history of proven paternity and no prior exposure to cannabis, received a THC edible once daily over the course of seven months. Their THC dose was based on published medical marijuana acclimation recommendations for humans, and was increased every 70 days in alignment with the animals' sperm development cycle. Dose adjustments were made until it reached the equivalent of a heavy medical marijuana dose in humans. Semen samples were collected at baseline before initiation of THC, and again at the end of each THC dosing timepoint.
"Our analysis of the collected samples found that THC use was associated with significant adverse impacts to the animals' reproductive hormones, including decreased levels of testosterone and severe testicular shrinkage. Specifically, we observed a greater than 50% decrease in testicular size," said the study's senior author Jamie Lo, M.D., M.C.R., associate professor of obstetrics and gynecology (perinatology and maternal-fetal medicine), OHSU School of Medicine, and Division of Reproductive & Developmental Sciences, Oregon National Primate Research Center at OHSU. "Unfortunately, these effects appeared to worsen as the THC dose was increased, suggesting a possible dose-dependent effect.
https://www.fertstert.org/article/S0015-0282(21)02321-9/fulltext
Hina Zahid Joined Medical Dialogue in 2017 with a passion to work as a Reporter. She coordinates with various national and international journals and association and covers all the stories related to Medical guidelines, Medical Journals, rare medical surgeries as well as all the updates in the medical field. Email:Â editorial@medicaldialogues.in. Contact no. 011-43720751
Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751