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  • Diuretic...

Diuretic spironolactone also reduces prostate cancer risk, finds study

Medha BaranwalWritten by Medha Baranwal Published On 2020-07-26T16:30:43+05:30  |  Updated On 26 July 2020 11:00 AM GMT
Diuretic spironolactone also reduces prostate cancer risk, finds study

Delhi: The use of spironolactone may lower the risk of prostate cancer, according to a recent study. The findings of the study were presented at the European Association of Urology 2020 virtual congress and subsequently published in the journal Prostate Cancer and Prostatic Diseases.Spironolactone is a cheap and effective diuretic used to manage heart failure and hypertension. It also...

Delhi: The use of spironolactone may lower the risk of prostate cancer, according to a recent study. The findings of the study were presented at the European Association of Urology 2020 virtual congress and subsequently published in the journal Prostate Cancer and Prostatic Diseases.

Spironolactone is a cheap and effective diuretic used to manage heart failure and hypertension. It also imparts anti-androgenic effects through its non-selective binding to steroid receptors and hence may also affect prostate cancer risk.

Kerri Beckmann, King's College London, London, UK, and colleagues investigated the association between spironolactone use and prostate cancer risk. For comparison, associations with thiazide diuretics which do not have anti-androgenic properties were also examined.

The researchers undertook a matched case-control study using population-wide data from the Prostate Cancer Data Base Sweden (PCBaSe). Al the cases of prostate cancer were matched by birth year and county with prostate-cancer free controls selected from the general population (1:5). associations between spironolactone use (dose and duration) and prostate cancer risk, and for thiazides were examined using multivariable conditional logistic regression.

Three percent of the 31,591 cases and 4% of the 156,802 controls were prescribed spironolactone.

Key findings of the study include:

  • Multivariable analyses indicated reduced risk of PCa among those ever exposed to spironolactone (odds ratio [OR] 0.83), with a stronger association for current users (OR: 0.77) than past users (OR: 0.88) and decreasing risk with increasing dose.
  • No association was observed for thiazide exposure and PCa risk.
  • Biases due to differences in prescribing patterns or frequency of PSA testing may have influenced these findings.

"Prostate cancer risk was reduced among men exposed to the diuretic spironolactone. Further investigation of spironolactone's potential chemopreventive effects is warranted," concluded the authors.

The study, "Spironolactone use is associated with lower prostate cancer risk: a population-wide case-control study," is published in the journal

DOI: https://doi.org/10.1038/s41391-020-0220-8


Prostate Cancer and Prostatic Diseases prostate cancer spironolactone 
Source : Prostate Cancer and Prostatic Diseases
Medha Baranwal
Medha Baranwal

    MSc. Biotechnology

    Medha Baranwal joined Medical Dialogues as an Editor in 2018 for Speciality Medical Dialogues. She covers several medical specialties including Cardiac Sciences, Dentistry, Diabetes and Endo, Diagnostics, ENT, Gastroenterology, Neurosciences, and Radiology. She has completed her Bachelors in Biomedical Sciences from DU and then pursued Masters in Biotechnology from Amity University. She has a working experience of 5 years in the field of medical research writing, scientific writing, content writing, and content management. She can be contacted at  editorial@medicaldialogues.in. Contact no. 011-43720751

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