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Prostate cancer survivors at higher risk of dementia: Study

Written By : Medha Baranwal |Medically Reviewed By : Dr. Kamal Kant Kohli Published On 2020-07-04T07:15:42+05:30  |  Updated On 4 July 2020 10:47 AM IST
Prostate cancer survivors at higher risk of dementia: Study
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Korea: Prostate cancer (PC) survivors may be at higher risk for dementia which might be due to the screening effects of PC, according to a recent study in the journal Current Problems in Cancer.

Jihun Kang, University College of Medicine, Busan, Republic of Korea, and colleagues conducted the study to investigate the effects of prostate cancer treatment, specifically androgen deprivation therapy (ADT) on dementia risk among PC survivors.

The study included a total of 51,252 patients newly diagnosed with PC from 2007 to 2013 who were matched with 209,659 non-cancer control. PC patients had no prior diagnosis of cancer or dementia.

Read Also: Prostate cancer: Oral relugolix bests inj leuprolide for rapid testosterone suppression

Key findings of the study include:

  • Compared to non-PC matched controls, PC survivors showed a slightly higher risk for dementia and Alzheimer's disease (AD) only in the screening cohort.
  • While PC survivors who underwent ADT were at a higher risk for dementia and AD, patients who underwent surgery were at a lower risk for dementia and AD, compared to the non-cancer population.
  • Compared to surgery, ADT, surgery + ADT, and active surveillance/watchful waiting showed a significantly elevated risk for dementia.

"Our results showed that compared to non-PC controls, prostate cancer survivors had a slightly higher risk for dementia that may be related to the screening effects of PC. Dementia risk was most prominent among PC patients who underwent ADT, followed by those who underwent AS/WW, and those who underwent surgery + ADT," wrote the authors.

"This suggests that individualized ADT strategies that consider the survival benefit and underlying dementia risk in PC survivors are necessary," they concluded.

Read Also: Inflammatory bowel disease linked to doubling in dementia risk

The study, "Risk of dementia in prostate cancer survivors: A nationwide cohort study in Korea," is published in the journal Current Problems in Cancer.

DOI: https://doi.org/10.1016/j.currproblcancer.2020.100578

Current Problems in Cancerdementiaprostate cancerAlzheimer diseaseandrogen deprivation therapy
Source : Current Problems in Cancer
Medha Baranwal
Medha Baranwal

    MSc. Biotechnology

    Dr. Kamal Kant Kohli
    Dr. Kamal Kant Kohli

    Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751

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