Varicocoele among adolescents not associated with testicular cancer

Elevated intrascrotal temperature has been suggested as a risk factor for testicular cancer, which is the most common neoplasm among young men. Varicocoele was linked to increased intrascrotal temperature, but whether it is associated with testicular cancer is unclear.

A study was explored the possible association between varicocoele at adolescence and the incidence of testicular cancer at adulthood.

This nationwide, population-based, historical cohort study includes 1,521,661 Israeli male adolescents (mean age 17.5 ± 0.4 years), who were screened for varicocoele during the years 1967–2012, as part of their medical assessment prior to compulsory military service. The mean follow-up was 18 ± 4.2 years.

The diagnosis of testicular cancer was ascertained from linkage of records to the the Israeli National Cancer Registry. Survival analysis was applied.

Results:

• In total, 53,210 adolescents were diagnosed with varicocoele stages 2 and 3 prior to military service. Of 1988 (0.13% of the total cohort) men who were diagnosed with testicular cancer during follow-up, 54 (0.1%) had varicocoele prior to military service, while 1934 (99.9%) did not.
• The age at cancer diagnosis and the distribution of seminomas versus non-seminomas did not differ significantly between those with and without varicocoele in adolescence.
• In a multivariable analysis controlling for sociodemographic factors, varicocoele was not associated with testicular cancer; odds ratio = 0.816

Thus, Varicocoele in adolescents was not found to be associated with testicular cancer in young adults.

Reference:

Guy Verhovsky, et al. Varicocoele in adolescence and testicular cancer in young adulthood. 06 September 2022. https://doi.org/10.1111/andr.13280

Keywords:

Guy Verhovsky, Moshe Giladi, Dorit Tzur, Arnon Afek, Lital Keinan-Boker, Estela Derazne, Dan Kaminsky, Azik Hoffman, Tomer Erlich, Tzahi Neuman, Varicocoele, adolescence, testicular, cancer, young adulthood, Andrology