HDL cholesterol levels not linked to risk of developing movement disorders, suggests research

Published On 2024-10-04 00:45 GMT | Update On 2024-10-04 09:49 GMT

HDL cholesterol levels not linked to risk of developing movement disorders, suggests research published in the Innovations in Clinical Neuroscience.

Well-known adverse events of antipsychotics are movement disorders, or extrapyramidal symptoms, such as drug-induced parkinsonism and tardive dyskinesia. With new evidence suggesting a link between low high-density lipoprotein cholesterol (HDL-C) and risk of Parkinson’s disease, this study sought to investigate if that link also translated to patients taking antipsychotics with low HDL-C and an increased risk for developing a movement disorder.

Adult patients (n=89) at an inpatient state psychiatric facility taking at least one antipsychotic with at least one HDL-C level were assessed for signs of a movement disorder through their history and physical, progress notes, and Abnormal Involuntary Movement Scale (AIMS) score. Results: There was no statistical significance when comparing a patient’s movement disorder, AIMS scores, and HDL-C levels to suggest that the HDL-C level influenced a patient’s movement disorder.

This study did not show a correlation between HDL-C levels and a patient’s risk of developing a movement disorder while taking an antipsychotic.

Reference:

O'Donnell C, Demler TL, Trigoboff E, Lee C. The Impact of High-density Lipoprotein Cholesterol (HDL-C) Levels and Risk of Movement Disorders in Patients Taking Antipsychotics. Innov Clin Neurosci. 2024 Jun 1;21(4-6):27-30. PMID: 38938537; PMCID: PMC11208005.

Article Source : Innovations in Clinical Neuroscience

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HDL cholesterol levels not linked to risk of developing movement disorders, suggests research

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