High-Potency Statins Found Most Effective in Lowering Bad Cholesterol: Study

New research published in Trends in Cardiovascular Medicine emphasizes the importance of aggressively lowering LDL cholesterol with high-dose statins to prevent and treat cardiovascular disease. In an invited editorial, experts from Florida Atlantic University’s Schmidt College of Medicine argue that potent statins like rosuvastatin and atorvastatin should be used as first-line pharmacologic therapies, alongside lifestyle interventions, to significantly reduce heart attack and stroke risks.

LDL, or low-density lipoprotein cholesterol, commonly known as "bad" cholesterol, is a major contributor to clogged arteries and cardiovascular events. Researchers analyzed a comprehensive body of randomized trial data and concluded that high-potency statins have the “strongest and most consistent body of evidence” for both prevention and treatment—across genders and age groups.

The authors, including senior author Dr. Charles H. Hennekens, highlighted the importance of starting treatment with maximum statin doses and reducing only if necessary. “Practicing cardiologists may wish to consider that all adjunctive drug therapies to therapeutic lifestyle changes should be added only after achieving maximal doses of statins,” said Hennekens.