Nicorandil reduces infarct size in STEMI patients undergoing primary PCI: JAHA
The latest trial found that administering nicorandil before primary percutaneous coronary intervention (pPCI) led to improved myocardial perfusion grade, increased left ventricular ejection fraction, and reduced myocardial infarct size in patients with ST‐segment–elevation myocardial infarction (STEMI). The study was published in the Journal of the American Heart Association.
Literature shows that Nicorandil improved microvascular dysfunction and reduced reperfusion injury when administered before primary percutaneous coronary intervention. Hence, researchers conducted a multicenter, prospective, randomized, double‐blind clinical trial called the CHANGE trial to investigate the effects of nicorandil administration on infarct size in patients with STEMI treated with primary percutaneous coronary intervention.
238 patients with STEMI participated in the study. Out of these 120 were randomized to receive intravenous nicorandil or placebo (n=118) before reperfusion. Patients in the nicorandil group received a 6‐mg intravenous bolus of nicorandil followed by continuous infusion at a rate of 6 mg/h. Patients in the placebo group received the same dose placebo. Infarct size on cardiac magnetic resonance (CMR) imaging performed at 5 to 7 days and 6 months after reperfusion was the primary endpoint.
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