Pretreatment with ticagrelor reduces troponin levels in stable CAD patients undergoing PCI
Italy: Pretreatment with a loading dose of ticagrelor (Brilinta) instead of prasugrel improves post-procedural microvascular function and coronary flow in patients with stable CAD (coronary artery disease) undergoing PCI, a small trial has shown. The findings of the trial were published in the BMJ journal Heart.
The research found that the periprocedural increase in high-sensitivity troponin I was significantly lower in the ticagrelor compared with the prasugrel group (5 (4, 9) ng/mL vs 14 (10, 24) ng/mL.
Emanuele Barbato, Department of Clinical and Molecular Medicine, Sapienza University of Rome, Rome, Italy, and colleagues aimed to compare the effects of prasugrel (Effient) and ticagrelor (Brilinta) on absolute coronary blood flow (Q) and microvascular resistance (R) in patients with stable CAD treated with elective PCI (percutaneous coronary intervention). Ticagrelor has been shown to have additional properties potentially affecting coronary microcirculation besides being at least as effective as prasugrel in inhibiting platelet aggregation.
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