Rivaroxaban superior to enoxaparin at preventing VTE after orthopedic surgeries
Written By : Dr. Kamal Kant Kohli
Published On 2020-04-06 16:00 GMT | Update On 2023-10-18 12:00 GMT
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Researchers have found that Rivaroxaban was more effective than enoxaparin for preventing venous thromboembolism (VTE) events without increasing bleeding risk in patients immobilized after nonmajor lower limb orthopedic surgery. The Late-Breaking Clinical Trial PRONOMOS was presented during ACC.20/WCC and simultaneously published in the New England Journal of Medicine.
The researchers conducted a randomized stratified trial to evaluate rivaroxaban compared with enoxaparin among patients immobilized after lower-limb nonmajor orthopedic surgery.
In the study the patients immobilized after orthopedic surgery were randomized to rivaroxaban 10 mg daily/enoxaparin placebo (n = 1,809) versus enoxaparin 4000 IU subcutaneous daily/rivaroxaban placebo (n = 1,795). The total number of enrollees was 3,604 withe mean patient age being 41 years and the total percentage of females participating in the trial was 34%.
The inclusion criteria were adults undergoing nonmajor orthopedic surgery of the lower limbs and requiring thromboprophylaxis for >2 weeks
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