Sleep restriction tied to persistent rise in BP in healthy young adults: Study
Although insufficient sleep is associated with increased cardiovascular risk, evidence of a causal relationship is lacking. As per a recent research published in Hypertension, researchers have observed that shortened sleep causes persistent elevation in 24-hour and sleep-time BP.
Naima Covassin and team from the Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN investigated the effects of prolonged sleep restriction on 24-hour ambulatory blood pressure (BP) and other cardiovascular measures in 20 healthy young participants aged 23.4±4.8 years, out of which 9 were females, all of whom underwent a randomized, controlled, crossover, 16-day inpatient study consisting of 4 days of acclimation, 9 days of sleep restriction (4 hours of sleep/night) or control sleep (9 hours), and 3 days of recovery.
These subjects consumed a weight maintenance diet with controlled nutrient composition throughout. A 24-hour BP (primary outcome) and cardiovascular biomarkers were measured repeatedly. Polysomnographic monitoring was continuous.
Comparing sleep restriction versus control sleep, it was observed that 24-hour mean BP was higher (adjusted mean difference, day 12: 2.1 mm Hg [95% CI, 0.6–3.6], corrected P=0.016), endothelial function was attenuated (P<0.001), and plasma norepinephrine increased (P=0.011).
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